Chymotrypsin-Like Activity of Proteasomes and Total Calpain Activity in Gastric and Colorectal Cancer
Chymotrypsin-Like Activity of Proteasomes and Total Calpain Activity in Gastric and Colorectal Cancer
复制标题
DOI：
10.1007/s10517-014-2666-y
复制
发表时间：
2014-10-01
影响因子：
0.7
通讯作者：
Cheremisina, O. V.
中科院分区：
文献类型：
--
作者：
Ivanova, E. V.;Kondakova, I. V.;Cheremisina, O. V.
研究了T2- 4 N 0 - 3 M0期胃癌和T2- 4 N 0 - 2 M0 -1期结直肠癌患者的蛋白酶体胰凝乳蛋白酶样活性和总钙蛋白酶活性。胃癌和结直肠癌组织中蛋白酶体和钙蛋白酶活性均高于相应正常组织。蛋白酶体和钙蛋白酶活性的变化是相互关联的。胃癌淋巴转移的出现与钙蛋白酶活性的增加有关。结直肠癌的进展和淋巴及血液转移的发生与蛋白酶体糜蛋白酶样活性升高有关。
Chymotrypsin-like activity of proteasomes and total calpain activity were studied in patients with stage T2-4N0-3M0 gastric cancer and stage T2-4N0-2M0-1 colorectal cancer. Activities of proteasomes and calpains in gastric and colorectal cancer tissues were higher than in the corresponding normal tissues. Changes in activities of proteasomes and calpains were mutually related. The appearance of lymphogenic metastases in gastric cancer was associated with the increase in calpain activity. The progress of colorectal cancer and development of lymphogenic and hematogenic metastases were associated with elevated chymotrypsin-like activity of proteasomes.