SPECTRAL-ANALYSIS OF BLOOD-PRESSURE AND HEART-RATE IN CONSCIOUS RATS - EFFECTS OF AUTONOMIC BLOCKERS
SPECTRAL-ANALYSIS OF BLOOD-PRESSURE AND HEART-RATE IN CONSCIOUS RATS - EFFECTS OF AUTONOMIC BLOCKERS
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DOI：
10.1016/0165-1838(90)90132-3
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发表时间：
1990-06-01
期刊：
影响因子：
--
通讯作者：
ELGHOZI, JL
中科院分区：
文献类型：
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作者：
JAPUNDZIC, N;GRICHOIS, ML;ELGHOZI, JL
我们研究了清醒大鼠血压和心率自发变异性的波动性。计算股动脉内血压，以200 ms间隔生成均匀间隔的信号（收缩压、舒张压、平均血压、心率）。这种等距采样允许使用快速傅立叶变换算法进行直接光谱分析。收缩压和心率表现出低频振荡（Mayer波，20-605 mHz）和与呼吸相关的高频振荡（1855 mHz）。迷走神经阻滞（阿托品）几乎消除了心率的呼吸波动。迷走神经阻滞或心交感神经阻滞（阿替洛尔）可减少低频心率波动。收缩压中的呼吸频率波动显著增加，交感神经阻滞（哌唑嗪）。相比之下，收缩压的低频振荡减少了α-交感神经阻滞这些数据表明，在有意识的大鼠中：（1）呼吸的心率振荡是迷走神经介导的;（2）低频范围内的心率波动是由β-交感神经和副交感神经活动;（3）收缩压中的呼吸振荡取决于心输出量的波动，并且通常被交感神经紧张抵消;（4）收缩压中的低频振荡反映了对阻力血管的交感神经活动。
We investigated the fluctuations which underly the spontaneous variability of blood pressure and heart rate in conscious rats. Intrafemoral blood pressure was computed to generate evenly spaced signals (systolic, diastolic, mean blood pressure, heart rate) at 200 ms intervals. This equidistant sampling allowed a direct spectral analysis using a Fast Fourier Transform algorithm. Systolic blood pressure and heart rate exhibited low-frequency oscillations (Mayer waves, 20-605 mHz) and a high- frequency oscillation related to respiration (1855 mHz). The respiratory fluctuations in heart rate was almost abolished by vagal blockade (atropine). Heart rate fluctuations in the low-frequency regime were diminished by vagal blockade or cardiac sympathetic blockade (atenolol). The respiratory frequency fluctuations in systolic blood pressure were markedly increased by .alpha.-sympathetic blockade (prazosin). In contrast, the low-frequency oscillations in systolic blood pressure were reduced by .alpha.-sympathetic blockade. These data indicate that in conscious rats: (1) the heart rate oscillation with respiration is vagally mediated; (2) the heart rate fluctuation in the low-frequency range is jointly mediated by .beta.-sympathetic and parasympathetic activities; (3) the respiratory oscillation in systolic blood pressure depends on fluctuations in cardiac output and is normally counteracted by the sympathetic tone; (4) the low-frequency oscillations in systolic blood pressure reflect the sympathetic activity to the resistance vessels.