Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth
Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth
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DOI：
10.1111/j.1651-2227.2006.00120.x
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发表时间：
2007-03-01
期刊：
影响因子：
3.8
通讯作者：
Sekiya, S.
中科院分区：
文献类型：
--
作者：
Kaku, K.;Osada, H.;Sekiya, S.
目的：胎儿出生时大小的正常变化是胎儿遗传因素和母体子宫环境相互作用的结果。然而，目前尚不清楚遗传因素是如何影响胎儿生长的。胰岛素样生长因子（IGF）系统调节子宫、胎盘和胎儿的发育，从而部分控制胎儿的生长速度。本研究的目的是探讨新生儿出生体重与IGF2和IGF2受体（IGF2R）基因多态性位点基因型之间的关系。方法：测定884对日本正常母亲及其新生儿的2个IGF2基因多态性位点和4个IGF2R基因多态性位点的基因型，并将基因型与按性别、胎次、分娩周数换算成的出生体重进行比较。结果：IGF2 +3123/ApaI基因型新生儿出生体重sds差异有统计学意义；IGF2R基因c.901C、b . 0g三种基因型新生儿出生体重差异均有统计学意义；结论：IGF2和IGF2R基因变异均与胎儿生长有关。
Aim: Normal variation in size at birth is a result of the interaction between fetal genetic factors and the maternal uterine environment. It is, however, unclear how genetic factors contribute to fetal growth. The insulin-like growth factor (IGF) system regulates uterine, placental and fetal development, thereby partially controlling the rate of fetal growth. The aim of this study was to investigate the associations between the neonatal birth weight and the genotypes of polymorphic loci in the IGF2 and IGF2 receptor (IGF2R) genes.Methods: We determined the genotypes of two polymorphic loci in the IGF2 gene and four loci in the IGF2R gene in 884 pairs of normal Japanese mothers and their neonates, and compared the genotypes with the birth weight converted into standard deviation scores (SDSs) according to sex, parity and gestational weeks at delivery.Results: There was a significant difference in birth weight SDSs among the three neonatal +3123/ApaI genotypes of the IGF2 gene; AA, AG and GG. There was also a significant difference in birth weight among the three neonatal c.901C > G genotypes of the IGF2R gene; CC, CG and GG.Conclusion: These findings indicate that both IGF2 and IGF2R gene variants are associated with fetal growth.