Visceral Adiposity Index, Triglyceride/High-Density Lipoprotein Ratio, and Lipid Accumulation Product Index to Discriminate Metabolic Syndrome Among Adult Type 1 Diabetes Patients
Visceral Adiposity Index, Triglyceride/High-Density Lipoprotein Ratio, and Lipid Accumulation Product Index to Discriminate Metabolic Syndrome Among Adult Type 1 Diabetes Patients
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DOI：
10.1089/met.2021.0047
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发表时间：
2021-07-20
影响因子：
2.1
通讯作者：
Beysel, Selvihan
中科院分区：
文献类型：
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作者：
Karatas, Savas;Beysel, Selvihan
背景资料：肥胖和代谢综合征（MetS）是1型糖尿病患者日益严重的问题;这些会影响临床并发症和治疗方案。内脏脂肪组织炎症在心血管并发症中起重要作用。内脏脂肪指数（VAI）、脂质蓄积指数（HDL）和甘油三酯（TG）/高密度脂蛋白（HDL）比值与胰岛素抵抗和内脏脂肪组织量密切相关。因此，本研究旨在研究和比较这些指标检测1型糖尿病（T1 DM）患者MetS的有用性。材料和方法：T1 DM患者和性别和年龄匹配的对照组被纳入本横断面研究。MetS的定义采用国际糖尿病联合会（IDF）、世界卫生组织（WHO）和国家胆固醇教育计划成人治疗组III（NCEP ATP III）标准。根据IDF标准将T1 DM患者分为两组。计算所有患者的VAI、TG和TG/HDL比值。各组进行相应比较。结果：126例T1 DM患者纳入研究。观察到VAI增加与MetS相关。MetS患者（32.2%）的VAI高于健康对照组（分别为8.21 ± 8.86; 3.49 ± 2.73，P < 0.01）。VAI的临界值为2.65 [曲线下面积（AUC）= 0.837，敏感性80.0%，特异性72.8%]，AUC为27.57 TG/HDL比值为2.18（AUC = 0.826，敏感性75.0%，特异性74.0%），均P < 0.001。结论：MetS在T1 DM中越来越常见。VAI、HDL、TG/HDL比值对T1 DM患者代谢综合征的预测有价值。
Background: Obesity and metabolic syndrome (MetS) are growing problems in type 1 diabetic patients; these can influence clinical complications and also treatment regimens. Visceral adipose tissue inflammation plays an important role in cardiovascular complications. Visceral adiposity index (VAI), lipid accumulation product index (LAP), and triglyceride (TG)/high-density lipoprotein (HDL) ratio have been strongly correlated with insulin resistance and visceral adipose tissue amount in previous studies. Therefore, this study aimed to investigate and compare the usefulness of these indices to detect MetS in patients with type 1 diabetes mellitus (T1DM). Materials and Methods: Patients with T1DM and gender- and age-matched controls were included in this cross-sectional study. MetS was defined using both International Diabetes Federation (IDF), World Health Organization (WHO), and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. T1DM patients were divided into two groups according to the IDF criteria. VAI, LAP, and TG/HDL ratio were calculated for all patients. Groups were compared accordingly. Results: One hundred twenty-six patients with T1DM were included in the study. Increased VAI was observed in association with MetS. Patients with MetS (32.2%) had the highest VAI than healthy controls (8.21 +/- 8.86; 3.49 +/- 2.73, respectively, P < 0.01). For determining MetS in type 1 diabetes, the cutoff value of VAI was 2.65 [area under the curve (AUC) = 0.837, sensitivity 80.0%, specificity 72.8%], LAP was 27.57 (AUC = 0.842, sensitivity 80.0%, specificity74.0%), TG/HDL ratio was 2.18 (AUC = 0.826, sensitivity 75.0%, specificity 74.0%), each P < 0.001. Conclusions: MetS becomes increasingly common in T1DM. VAI, LAP, and TG/HDL ratio were useful for predicting MetS in patients with T1DM.