The production of rhythmically recurrent cortical potentials after localized thalamic stimulation
The production of rhythmically recurrent cortical potentials after localized thalamic stimulation
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DOI：
10.1152/ajplegacy.1941.135.2.293
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发表时间：
1942-01-01
影响因子：
--
通讯作者：
Morison, RS
中科院分区：
文献类型：
--
作者：
Dempsey, EW;Morison, RS
用一系列缓慢的刺激刺激丘脑内侧区域，可产生 20 至 35 个杂项的募集潜力。潜伏期广泛存在于皮质中。这种反应每秒自发8-12次。爆发潜力在以下方面相似。两种电位的分布和大小相似。募集电位以接近每秒 8-12 次自发刺激的频率准确跟踪。活动。频率较慢时，每秒有 8-12 趟列车。出现与刺激不同步的活动。更快的刺激频率会导致刺激期间募集电位的崩溃和自发电位的消除。初始募集效应的大小与其被诱导的自发爆发的阶段相关。以适当速率长时间持续刺激会导致周期性的募集和解除募集，类似于自发爆发的盛衰。自发电位和募集电位都是从除丘脑连接之外的隔离皮质区域记录的。因此，这两种效应都不依赖于长的皮质内连接。当研究各种皮层反应的相互作用时，募集电位和自发电位在行为上表现出本质的相似性。由于以上考虑，建议招募和自发8-12次每秒。潜力是相同的。
Stimulation of medial thalamic regions with a slow series of stimuli set up a recruiting potential of 20 to 35 misc. latency which was widespread in the cortex. This response and the spontaneous 8-12 per sec. burst potentials were similar in the following respects. The distribution and magnitude of the 2 potentials were similar. The recruiting potentials followed accurately at stimulus frequencies near those of the spontaneous 8-12 per sec. activity. At slower frequencies, trains of 8-12 per sec. activity appeared which were out of phase with the stimuli. Faster stimulus frequencies caused a breakdown of the recruited potential and an abolition of the spontaneous potentials during the period of stimulation. The size of the initial recruiting effect was related to the phase of the spontaneous burst at which it was induced. Long continued stimulation at appropriate rates led to a periodic recruitment and de-recruitment similar to the waxing and waning of the spontaneous bursts. Both spontaneous and recruited potentials were recorded from areas of cortex isolated except for their thalamic connections. Neither effect depended, therefore, upon long intracortical connections. Recruited and spontaneous potentials showed essential similarities in behavior when the interaction of various cortical responses was studied. Because of the above considerations it is suggested that the recruited and the spontaneous 8-12 per sec. potentials are identical.