Postural sway and effect of levodopa in early Parkinson's disease
Postural sway and effect of levodopa in early Parkinson's disease
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DOI：
10.1017/s0317167100007575
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发表时间：
2008-03-01
影响因子：
3
通讯作者：
Blanchet, Pierre J.
中科院分区：
文献类型：
--
作者：
Beuter, Anne;Hernandez, Roberto;Blanchet, Pierre J.
目的：探讨早期帕金森病（PD）患者的姿势稳定性控制和左旋多巴反应性。方法：对10例PD发病6年内的患者，在常规口服左旋多巴前（OFF）和后（ON）静位时的体位摇摆进行研究。使用力平台记录眼睁开30秒的体位摇摆，并检查6个因变量。结果：在我们的患者中记录了轻微的基线亚临床变化。在ON条件下，6个特征（平均摆动、横向摆动、矢状摆动、摆动强度和摆动面积）中有5个明显受益。结论：PD患者的体位控制机制在早期受到影响，并受多巴胺调节。
Objective: To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD). Methods: Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined. Results: Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition. Conclusion: Postural control mechanisms are affected early in PD and modulated by dopamine.