Amygdala structure and aggressiveness in borderline personality disorder
Amygdala structure and aggressiveness in borderline personality disorder
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DOI：
10.1007/s00406-016-0747-9
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发表时间：
2018-06-01
影响因子：
4.7
通讯作者：
Bertsch，Katja
中科院分区：
文献类型：
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作者：
Mancke，Falk;Herpertz，Sabine C.;Bertsch，Katja
攻击性被认为是边缘型人格障碍（BPD）的一个重要临床特征，并与杏仁核的改变有关。然而，分析BPD中与攻击性相关的杏仁核改变的确切位置或系统地比较女性和男性BPD患者的研究缺失。因此，在目前的研究中，我们研究了BPD患者和健康志愿者的性别混合样本，并应用了一种自动分割方法，该方法允许研究杏仁核体积和局部杏仁核形状的变化。体积测量结果显示BPD患者和健康志愿者的杏仁核体积没有差异，但男性BPD患者的右侧杏仁核体积与攻击性之间存在正相关趋势。杏仁核形状的分析表明，在左侧基底杏仁核中，性别相互作用效应呈组间趋势，亚组分析无差异。最后，男性BPD患者的左侧浅杏仁核和外侧基底杏仁核区域与攻击性呈正相关。总之，我们的研究结果强调需要考虑性别特异性的影响，并证明男性BPD患者的攻击性和杏仁核区域，特别是与社会信息处理和联想情绪学习之间的联系。
Aggressiveness is considered an important clinical feature of borderline personality disorder (BPD) and has been associated with alterations of the amygdala. However, studies that analyzed the exact location of amygdala alterations associated with aggressiveness in BPD or that systematically compared female and male BPD patients are missing. In the current study, we therefore investigated a sex-mixed sample of BPD patients and healthy volunteers and applied an automated segmentation method that allows the study of both, alterations of amygdala volume and localized amygdala shape. Volumetric results revealed no difference in amygdala volume between BPD patients and healthy volunteers, but a trend for a positive association between volume of the right amygdala and aggressiveness in male BPD patients. Analyses of amygdala shape showed a trend for a group by sex interaction effect in the left laterobasal amygdala, without a difference in subgroup analyses. Finally, regions of the left superficial and laterobasal amygdala of male BPD patients were positively associated with aggressiveness. In sum, our results emphasize the need to consider sex-specific effects and demonstrate a link between male BPD patients’ aggressiveness and amygdala regions that are particularly related to social information processing and associative emotional learning.