A specific beta(3)-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats
A specific beta(3)-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats
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DOI：
10.1016/0014-2999(95)00802-0
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发表时间：
1996-03-18
影响因子：
5
通讯作者：
Penicaud, L
中科院分区：
文献类型：
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作者：
Atef, N;Lafontan, M;Penicaud, L
为了研究β 3-肾上腺素受体刺激对mts胰岛素分泌的作用，在CL 316243（化学名称为（R，R）-5-[2-[[2，3-（3-氯苯基）-2-羟乙基]氨基]丙基]-1，3-苯并间二氧杂环戊烯-2，2-二羧酸二钠，一种特异性β 3-肾上腺素受体激动剂）治疗期间测定了血浆胰岛素水平和胰岛血流量。CL 316243诱导胰岛血流量和血浆胰岛素浓度显著增加，而全胰腺血流量无变化。当用β（1）、β（2）、β（3）肾上腺素能受体拮抗剂布萘洛尔预处理大鼠时，这种增加被完全阻止，但用β（1）、β（2）肾上腺素能受体拮抗剂纳多洛尔则不能。我们的结论是，β（3）-肾上腺素受体刺激引起了显着的血管扩张的胰岛中的微血管，这反过来又可能有助于增加胰岛素分泌。
In order to study the role of beta(3)-adrenoceptor stimulation on insulin secretion in mts, plasma insulin level and islet blood flow were measured during treatment with CL 316243 which is chemically named disodium (R, R)-5-[2-[[2,3-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate, a specific beta(3)-adrenoceptor agonist. CL 316243 induced a marked increase in both islet blood flow and plasma insulin concentration without changes in whole pancreatic blood flow. This increase was totally prevented when the rats were pretreated with bupranolol, a beta(1),beta(2),beta(3)-adrenoceptor antagonist, but not with nadolol, a beta(1),beta(2)-adrenoceptor antagonist. We conclude that beta(3)-adrenoceptor stimulation provokes a marked vasodilatation of microvessels in the islets of Langerhans, which in turn could contribute to the increase in insulin secretion.