Relationship between diffusion tensor fractional anisotropy and motor outcome in patients with hemiparesis after corona radiata infarct
Relationship between diffusion tensor fractional anisotropy and motor outcome in patients with hemiparesis after corona radiata infarct
复制标题
放射冠梗塞后偏瘫患者弥散张量各向异性分数与运动结局的关系
DOI：
10.1016/j.jstrokecerebrovasdis.2013.02.017
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Domen K
中科院分区：
文献类型：
--
作者：
Koyama T;Marumoto K;Miyake H;Domen K
本研究探讨了15例放射冠病变缺血性卒中后轻偏瘫患者磁共振弥散张量成像（DTI）的各向异性分数（FA）值与运动结局（发病后1个月）之间的关系。在第14-18天获得DTI数据。使用计算机自动化方法分析大脑脚内的FA值。根据Brunnstrom分级（BRS; 6分量表：重度至正常），分别评估肩/肘/前臂、腕/手和下肢功能的轻偏瘫运动结局。根据BRS数据评估受累半球与未受累半球FA值的比值（rFA）（斯皮尔曼等级相关检验，P<0.05）。rFA值范围为0.715 - 1.002（中位数= 0.924）。肩/肘/前臂的BRS范围为1 - 6（中位数= 4），腕/手的BRS范围为1 - 6（中位数= 5），下肢的BRS范围为2 - 6（中位数= 4）。分析显示rFA与上肢功能之间存在统计学显着关系（肩/肘/前臂的相关系数= 0.679，腕/手的相关系数= 0.706）。尽管不太明显，但RFA与下肢功能之间的关系也具有统计学显著性（相关系数= 0.641）。大脑脚的FA值与上肢和下肢功能的结果中度相关，这表明DTI可能适用于放射冠梗死卒中患者的预后预测。
This study examined the relationship between fractional anisotropy (FA) values of magnetic resonance-diffusion tensor imaging (DTI) and motor outcome (1 month after onset) in 15 patients with hemiparesis after ischemic stroke of corona radiata lesions. DTI data were obtained on days 14-18. FA values within the cerebral peduncle were analyzed using a computer-automated method. Motor outcome of hemiparesis was evaluated according to Brunnstrom stage (BRS; 6-point scale: severe to normal) for separate shoulder/elbow/forearm, wrist/hand, and lower extremity functions. The ratio of FA values in the affected hemisphere to those in the unaffected hemisphere (rFA) was assessed in relation to the BRS data (Spearman rank correlation test,P< .05). rFA values ranged from .715 to 1.002 (median = .924). BRS ranged from 1 to 6 (median = 4) for shoulder/elbow/forearm, from 1 to 6 (median = 5) for wrist/hand, and from 2 to 6 (median = 4) for the lower extremities. Analysis revealed statistically significant relationships between rFA and upper extremity functions (correlation coefficient = .679 for shoulder/elbow/forearm and .706 for wrist/hand). Although slightly less evident, the relationship between rFA and lower extremity function was also statistically significant (correlation coefficient = .641). FA values within the cerebral peduncle are moderately associated with the outcome of both upper and lower extremity functions, suggesting that DTI may be applicable for outcome prediction in stroke patients with corona radiata infarct.