Nontuberculous Mycobacterial Disease and Molybdenum in Colorado Watersheds
Nontuberculous Mycobacterial Disease and Molybdenum in Colorado Watersheds
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DOI：
10.3390/ijerph17113854
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发表时间：
2020-06-01
影响因子：
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通讯作者：
Crooks, James L.
中科院分区：
文献类型：
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作者：
Lipner, Ettie M.;French, Joshua;Crooks, James L.
非结核分枝杆菌（NTM）是可能导致慢性肺部疾病的环境细菌。有利于NTM生长的环境因素可能会增加特定环境中NTM暴露的风险。我们的目的是确定水质成分（铝，砷，镉，钙，铜，铁，铅，镁，锰，钼，镍，钾，硒，钠，锌和pH值）与跨科罗拉多流域的NTM疾病。我们进行了一项地理空间生态研究，将在国家犹太健康中心接受治疗的NTM疾病患者的数据与水质门户网站的水质数据相关联。与疾病风险相关的水质成分确定广义线性模型与泊松分布离散响应。我们观察到水源中的钼（Mo）与疾病风险之间存在高度相关性。水源中钼的对数浓度每增加1个单位，疾病风险增加17.0%。我们还观察到水源中的钙（Ca）与疾病风险之间存在统计学显著相关性。NTM的风险因流域而异，并与流域特定的水质成分。这些发现可以为降低总体暴露风险的缓解策略提供信息。
Nontuberculous mycobacteria (NTM) are environmental bacteria that may cause chronic lung disease. Environmental factors that favor NTM growth likely increase the risk of NTM exposure within specific environments. We aimed to identify water-quality constituents (Al, As, Cd, Ca, Cu, Fe, Pb, Mg, Mn, Mo, Ni, K, Se, Na, Zn, and pH) associated with NTM disease across Colorado watersheds. We conducted a geospatial, ecological study, associating data from patients with NTM disease treated at National Jewish Health and water-quality data from the Water Quality Portal. Water-quality constituents associated with disease risk were identified using generalized linear models with Poisson-distributed discrete responses. We observed a highly robust association between molybdenum (Mo) in the source water and disease risk. For every 1- unit increase in the log concentration of molybdenum in the source water, disease risk increased by 17.0%. We also observed a statistically significant association between calcium (Ca) in the source water and disease risk. The risk of NTM varied by watershed and was associated with watershed-specific water-quality constituents. These findings may inform mitigation strategies to decrease the overall risk of exposure.