Socio-behavioral and geographic correlates of prevalent hepatitis C virus infection among young injection drug users in metropolitan Baltimore and Chicago
Socio-behavioral and geographic correlates of prevalent hepatitis C virus infection among young injection drug users in metropolitan Baltimore and Chicago
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DOI：
10.1016/j.drugalcdep.2010.04.003
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发表时间：
2010-09-01
影响因子：
4.2
通讯作者：
Ouellet, Lawrence J.
中科院分区：
文献类型：
--
作者：
Boodram, Basmattee;Golub, Elizabeth T.;Ouellet, Lawrence J.
背景：丙型肝炎病毒(丙型肝炎病毒)在年轻注射吸毒者(IDU)中的感染率在美国不同城市之间有很大差异。年龄在15-30岁的注射吸毒者被招募参加在美国五个城市进行的第三次协作性注射吸毒者研究，方法是受访者驱动的方法。我们的横断面研究考察了巴尔的摩(n=736)和芝加哥(n=586)研究地点流行的丙型肝炎病毒感染(丙型肝炎病毒+)的相关性和地理分布。我们评估了通过计算机辅助的自我访谈和人类免疫缺陷病毒以及甲型、乙型和丙型肝炎的血清抗体检测收集的基线社会人口学和行为数据。结果：丙型肝炎病毒在巴尔的摩的感染率为53.0%，在芝加哥为13.7%(p<；0.0001)。与芝加哥相比，巴尔的摩的参与者显著(p<；0.05)更有可能年龄更大，合并感染艾滋病毒和其他肝炎病毒，居住在城市地区，主要注射可卡因，在公共场所注射，使用用过的注射器和用具注射，注射时间更长；他们不太可能使用注射器交换计划。然而，在多变量Logistic回归中考虑了社会人口学和行为危险因素后，城市是丙型肝炎流行的最强预测因素(巴尔的摩和芝加哥调整后的优势比=3.5[95%可信区间，2.2-5.6])。地理空间分析显示，巴尔的摩几乎一半的丙型肝炎病毒+参与者居住在5英里的城市区域内，而芝加哥参与者分散在大都市地区。结论：两个城市之间不同的丙型肝炎病毒流行率仅部分由个人水平的因素解释。未来的研究应该检查年轻注射吸毒者的网络配置和注射伙伴的特征。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Hepatitis C virus (HCV) infection prevalence among young injection drug users (IDUs) differs substantially between cities in the United States (U.S.).Methods: Between 2002 and 2004. IDUs aged 15-30 were recruited for the Third Collaborative Injection Drug User Study in five U.S. cities using respondent-driven methods. Our cross-sectional study examined correlates and geographic distribution of prevalent HCV infection (HCV+) from the Baltimore (n = 736) and Chicago (n = 586) study sites. We evaluated baseline socio-demographic and behavioral data collected from computer-assisted self-interviews and serological antibody testing for human immunodeficiency virus (HIV) and hepatitis A, B, and C.Results: HCV prevalence was 53.0% in Baltimore and 13.7% in Chicago (p < 0.0001). Baltimore compared to Chicago participants were significantly (p < 0.05) more likely to be older, co-infected with HIV and other hepatitis viruses, reside in an urban area, inject primarily cocaine, inject in public settings, inject with used syringes and paraphernalia, and have been injecting longer; they were less likely to utilize syringe exchange programs. However, after accounting for socio-demographic and behavioral risk factors in multivariable logistic regression, city was the strongest predictor of HCV prevalence (Baltimore versus Chicago adjusted odds ratio = 3.5 [95% confidence interval, 2.2-5.6]). Geospatial analyses showed that almost half of all HCV+ participants in Baltimore resided within a 5-mile urban area, while Chicago participants were dispersed across the metropolitan area.Conclusions: The disparate HCV prevalence between the two cities is only partially explained by individual-level factors. Future studies should examine the network configurations and injection partners' characteristics of young IDUs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.