Study of drugs affecting cholesterol-induced atherosclerosis in rabbits.
Study of drugs affecting cholesterol-induced atherosclerosis in rabbits.
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影响胆固醇引起的家兔动脉粥样硬化的药物研究。
DOI：
10.1007/978-1-4614-4618-7_9
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发表时间：
1976
影响因子：
--
通讯作者：
D. N. Kim
中科院分区：
文献类型：
--
作者：
Y. S. Kwak;K. T. Lee;D. N. Kim
1.研究了不同药物对兔胆固醇诱导的动脉粥样硬化进展阶段的影响。测试的药物是抗代谢物（巯基嘌呤、羟基脲）、表面活性剂（十二烷基硫酸钠）、肾上腺皮质类固醇合成抑制剂（o，p '-DDD）、溶酶体稳定剂（氯喹、乙酰水杨酸）、抗组胺剂（氯苯那敏）和胆固醇结合剂（制霉菌素）。2.巯嘌呤治疗显示动脉粥样硬化病变以及血清和主动脉的胆固醇浓度均明显降低。3.羟基脲降低了主动脉胆固醇浓度和病变，但血清胆固醇浓度仍然很高。4.十二烷基硫酸钠和o，o '-DDD对动脉粥样硬化的形成有轻微的抑制作用。5.吡啶氨基甲酸酯只有在餐前给药时才对预防动脉粥样硬化有轻微的有益作用。6.制霉菌素、氯喹和乙酰水杨酸+扑尔敏的作用不大。
1. Effects of various drugs on cholesterol-induced atherosclerosis in rabbits during the progression phase have been studied. The drugs tested are antimetabolites (mercaptopurine, hydroxyurea), surface active agents (sodiumdodecyl sulfate), inhibitor of adrenocoritcal steroid synthesis (o, p'-DDD), lysosome stablizers (chloroquine, acetylsalicylic acid) with antihistaminic (chlorpheniramine) and cholesterol binder (nystatin). 2. Mercaptopurine treatment showed marekd reduction in both atherosclerotic lesions and cholesterol concentrations of the serum and aorta. 3. Hydroxyurea reduced both the aortic cholesterol concentration and the lesions, but the serum cholesterol concentration remained high. 4. Sodiumdodecyl sulfate and o, o'-DDD showed slight inhibition of the development of atherosclerosis. 5. Pyridinocarbamate showed a slight beneficial effect on the prevention of atherosclerosis only when it was administered prior to the meal. 6. Nystatin, chloroquine and acetylsalicylic acid + chlorpheniramine showed little effect.