Human Infection with a Triple-Reassortant Swine Influenza A(H1N1) Virus Containing the Hemagglutinin and Neuraminidase Genes of Seasonal Influenza Virus
Human Infection with a Triple-Reassortant Swine Influenza A(H1N1) Virus Containing the Hemagglutinin and Neuraminidase Genes of Seasonal Influenza Virus
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DOI：
10.1086/651507
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发表时间：
2010-04-15
影响因子：
6.4
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Bastien, Nathalie;Antonishyn, Nick A.;Li, Yan
从 3 名患者体内分离出一种猪源性甲型 H1N1 流感重配病毒，与 2009 年大流行的 H1N1 病毒株不同，这三名患者都在加拿大萨斯喀彻温省的同一家大型养猪场工作。据我们所知，这些分离株的基因组组成此前尚未报道过，是季节性 H1N1 流感病毒与 20 世纪 90 年代末北美猪中出现的三重重配流感病毒之间基因重配的产物。 A/Saskatchewan/5350/2009、A/Saskatchewan/5351/2009和A/Saskatchewan/5131/2009的神经氨酸酶和血凝素基因源自人类H1N1病毒，与A/Brisbane/59/2007的神经氨酸酶和血凝素基因密切相关。
A reassortant influenza A(H1N1) virus of swine origin distinct from the pandemic H1N1 2009 strain was isolated from 3 patients, all of whom worked at the same large hog operation in Saskatchewan, Canada. The genomic composition of the isolates has not been previously reported, to our knowledge, and was the product of a genetic reassortment between seasonal H1N1 and triple-reassortant influenza virus that emerged in North American swine during the late 1990s. The neuraminidase and hemagglutinin genes of A/Saskatchewan/5350/2009, A/Saskatchewan/5351/2009, and A/Saskatchewan/5131/2009 were derived from human H1N1 virus and were closely related to those of A/Brisbane/59/2007.