Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration.
Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration.
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环 ADP-核糖和 NAADP 的钙信号传导。
DOI：
10.1007/bf02738306
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Lee,HC
中科院分区：
文献类型：
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作者：
Lee,HC
随着第一个Ca 2+信使三磷酸肌醇（IP 3）的发现，Ca 2+动员作为一种信号传导机制已被置于中心舞台。本文重点介绍了两种新的钙释放激活剂，通过完全独立于IP 3的机制调动内部钙库。它们是环状ADP-核糖（cADPR）和烟酸二核苷酸磷酸（NAADP），分别来自NAD和NADP的代谢产物。在过去的十年中，这两个新的信号机制的理解的主要进展按时间顺序进行了总结。
Ca2+mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+release activators, which mobilize internal Ca2+stores via mechanisms totally independent of IP3. They are cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP), metabolites derived respectively from NAD and NADP. Major advances in the past decade in the understanding of these two novel signaling mechanisms are chronologically summarized.