Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart
Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart
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DOI：
10.1016/s0140-6736(13)60777-1
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发表时间：
2013-11-02
期刊：
影响因子：
168.9
通讯作者：
Vaupel, James W.
中科院分区：
文献类型：
--
作者：
Christensen, Kaare;Thinggaard, Mikael;Vaupel, James W.
背景在高收入国家，活到10岁的人口比例迅速增加。人们普遍关切的是，这种发展的基础是体弱和残疾的老年人活到很老。为了调查这个问题，我们比较了两个队列的丹麦nonagenarians，出生10 years apart.Methods人在第一个队列出生于1905年，并在93岁（n=2262）进行评估，在第二个队列出生于1915年，并在95岁（n=1584）进行评估的认知和身体功能。所有队列成员都有资格，无论居住类型如何。两个队列都通过使用相同设计和评估工具的调查进行评估，并且具有几乎相同的应答率（63%）。认知功能通过简易精神状态检查和对年龄相关变化敏感的五项认知测试的复合物进行评估。通过日常生活活动评分和体能测试评估身体功能结果1915年队列中从出生到93岁的存活率比1905年队列高28% 1915年队列中达到95岁的机会高出32%（3.93% vs 2.98%）。1915年队列在简易精神状态检查中的得分显著高于1905年队列（22.8 [SD 5.6] vs 21.4 [6.0]; p
Background A rapidly increasing proportion of people in high-income countries are surviving into their tenth decade. Concern is widespread that the basis for this development is the survival of frail and disabled elderly people into very old age. To investigate this issue, we compared the cognitive and physical functioning of two cohorts of Danish nonagenarians, born 10 years apart.Methods People in the first cohort were born in 1905 and assessed at age 93 years (n=2262); those in the second cohort were born in 1915 and assessed at age 95 years (n=1584). All cohort members were eligible irrespective of type of residence. Both cohorts were assessed by surveys that used the same design and assessment instrument, and had almost identical response rates (63%). Cognitive functioning was assessed by mini-mental state examination and a composite of five cognitive tests that are sensitive to age-related changes. Physical functioning was assessed by an activities of daily living score and by physical performance tests (grip strength, chair stand, and gait speed).Findings The chance of surviving from birth to age 93 years was 28% higher in the 1915 cohort than in the 1905 cohort (6.50% vs 5.06%), and the chance of reaching 95 years was 32% higher in 1915 cohort (3.93% vs 2.98%). The 1915 cohort scored significantly better on the mini-mental state examination than did the 1905 cohort (22.8 [SD 5.6] vs 21.4 [6.0]; p