Synthesis of Novel Biomimetic Zwitterionic Phosphorylcholine-Bound Chitosan Derivative
Synthesis of Novel Biomimetic Zwitterionic Phosphorylcholine-Bound Chitosan Derivative
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DOI：
10.1002/marc.200500876
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发表时间：
2006-04
影响因子：
4.6
通讯作者：
R. Zeng;H. Fu;Yufen Zhao
中科院分区：
文献类型：
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作者：
R. Zeng;H. Fu;Yufen Zhao
在温和条件下，通过Atherton-Todd反应，有效地制备了缀合两性离子磷酰胆碱的水溶性仿生壳聚糖衍生物，两性离子产物的可能形成机制与D-氨基葡萄糖残基上相邻的3-羟基在碱的作用下对磷的亲核攻击有关。 DNA/磷酸胆碱结合壳聚糖衍生物的紫外吸收和熔化行为表明，磷酸胆碱结合壳聚糖衍生物可以成为长循环大分子药物递送的新载体。
Water-soluble biomimetic chitosan derivative conjugating zwitterionic phosphorylchline was evviciently prepared through Atherton-Todd reaction under the mild conditions, and the possible formation mechanism of zwitterionic product was related to the nucleophilic attack of afjacent 3-hydroxyl on the D-glucosamine residue to phosphorus with the help of base. UV absorption and melting behaviors of DNA/phosphorylcholine-bound chitosan derivative showed that the phosphorylcholine-bound chitosan derivative could he a new carrier for long-circulating macromolecular drug delivery.