Immunological pathogenesis of inflammatory bowel disease.
Immunological pathogenesis of inflammatory bowel disease.
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DOI：
10.5217/ir.2018.16.1.26
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发表时间：
2018-01
影响因子：
4.9
通讯作者：
Cho ML
中科院分区：
文献类型：
--
作者：
Lee SH;Kwon JE;Cho ML
炎症性肠病（IBD）是胃肠道的慢性炎症状态，可分为两种主要临床现象：克罗恩病（CD）和溃疡性结肠炎（UC）。IBD（包括CD和UC）的发病机制涉及致病因素的存在，如肠道菌群异常、免疫应答失调、环境变化和基因变异。虽然许多研究试图确定与IBD相关的新致病因素，这些因素与环境、遗传、微生物和免疫反应因素有关，但对IBD发病机制的全面了解尚不清楚。因此，IBD治疗远非最佳，患者结局可能不令人满意。随着对IBD的大量研究，Th17细胞和先天性淋巴样细胞（inatelymphocyte，ILC）在IBD发病中的作用被研究。最近一项关于Th17细胞可塑性的研究主要集中在结肠炎上。ILC也是一个新的细胞家族，在IBD的发病机制中发挥重要作用. IBD免疫发病机制是理解IBD病因的关键，并可导致IBD疗法的发展。本文综述了炎症性肠病的发病机制，重点是免疫因素和治疗方法。
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD, including CD and UC, involves the presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes, and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear. Thus, IBD treatment is far from optimal, and patient outcomes can be unsatisfactory. As result of massive studying on IBD, T helper 17 (Th17) cells and innate lymphoid cells (ILCs) are investigated on their effects on IBD. A recent study of the plasticity of Th17 cells focused primarily on colitis. ILCs also emerging as novel cell family, which play a role in the pathogenesis of IBD. IBD immunopathogenesis is key to understanding the causes of IBD and can lead to the development of IBD therapies. The aim of this review is to explain the pathogenesis of IBD, with a focus on immunological factors and therapies.