Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments
Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments
复制标题
DOI：
10.1002/nbm.4061
复制
发表时间：
2019-03-01
影响因子：
2.9
通讯作者：
Gowland, Penny A.
中科院分区：
文献类型：
--
作者：
Wesolowski, Roman;Blockley, Nicholas P.;Gowland, Penny A.
更好地理解脑血流量（CBF）和脑血容量（CBV）变化之间的耦合对于进一步理解BOLD反应至关重要。本研究的目的是测量神经激活过程中不同血管室的CBF-CBV耦合。在视觉刺激期间测量三个血流动力学参数。Look-Flow-Sensitive交替反转恢复用于测量CBF和动脉CBV（CBVa）的变化，使用针对每种对比度优化的序列参数。使用钆基造影剂技术测量总CBV（CBVtot）的变化。基于在CBF实验中激活的体素，从感兴趣区域提取血液动力学变化。CBF-CBVtot偶联常数α（tot）测量为0.16 +/- 0.14，CBF-CBVa偶联常数α（a）测量为0.65 +/- 0.24。使用脉管系统（动脉和静脉）的二室模型，针对基线动脉和静脉血容量的假设值预测静脉CBV（CBVv）的变化。这些结果将提高依赖于BOLD响应模型的应用程序的准确性和可靠性，例如校准的BOLD。
A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vascular compartments during neural activation. Three haemodynamic parameters were measured during a visual stimulus. Look-Locker flow-sensitive alternating inversion recovery was used to measure changes in CBF and arterial CBV (CBVa) using sequence parameters optimized for each contrast. Changes in total CBV (CBVtot) were measured using a gadolinium-based contrast agent technique. Haemodynamic changes were extracted from a region of interest based on voxels that were activated in the CBF experiments. The CBF-CBVtot coupling constant alpha(tot) was measured as 0.16 +/- 0.14 and the CBF-CBVa coupling constant alpha(a) was measured as 0.65 +/- 0.24. Using a two-compartment model of the vasculature (arterial and venous), the change in venous CBV (CBVv) was predicted for an assumed value of baseline arterial and venous blood volume. These results will enhance the accuracy and reliability of applications that rely on models of the BOLD response, such as calibrated BOLD.