CONCURRENT EXPOSURE TO LEAD, MANGANESE, AND CADMIUM AND THEIR DISTRIBUTION TO VARIOUS BRAIN-REGIONS, LIVER, KIDNEY, AND TESTIS OF GROWING-RATS
CONCURRENT EXPOSURE TO LEAD, MANGANESE, AND CADMIUM AND THEIR DISTRIBUTION TO VARIOUS BRAIN-REGIONS, LIVER, KIDNEY, AND TESTIS OF GROWING-RATS
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DOI：
10.1007/bf01054947
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发表时间：
1987-05-01
影响因子：
4
通讯作者：
CHANDRA, SV
中科院分区：
文献类型：
--
作者：
SHUKLA, GS;CHANDRA, SV
将生长期大鼠暴露于5 mg/L铅，自由饮水，腹腔注射低剂量或高剂量锰和镉（i. p.）30天一些组的动物也以相同的方式给予铅+锰和铅+镉的组合。组织样本中的铅，锰，镉的分析表明，预期的剂量依赖性积累时，金属单独管理。然而，联合治疗在不同组织中产生不同类型的金属移位。所有三种金属在大脑中的积累增加，锰在肝脏中，铅在肾脏中，镉在睾丸和肾脏联合暴露后，可能会使目标器官容易受到金属的毒性作用，即使在低浓度时遇到。此外，血铅水平的降低后，联合治疗镉或锰表明，显着的血铅水平作为一个诊断援助铅毒性在共同暴露条件下可能没有太大的价值。共暴露后组织内金属分布的变化可能是所施用金属之间竞争共同结合位点的结果。
Growing rats were exposed to 5 mg/L Pb, ad libitum in drinking water, and administered low or high doses of Mn and Cd intraperitoneal (i.p.) for 30 days. Some groups of animals were also administered combinations of Pb + Mn and Pb + Cd in an identical manner. Analysis of Pb, Mn, and Cd in tissue samples showed the expected dose-dependent accumulation when the metal was administered singly. However, combined treatment produced different types of metal shift in different tissues. Enhanced accumulation of all three metals in the brain, Mn in liver, Pb in kidney and Cd in testis and kidney after combined exposure may make target organs vulnerable to the toxic effects of metals, even when encountered at low concentrations. Further, the decreased levels of blood Pb after combined treatment with Cd or Mn suggests that the significant of blood Pb level as a diagnostic aid for Pb toxicity in coexposed conditions may not be of much value. Changes in the metallic distribution within the tissues after coexposure may be the result of a competition between the administered metals for common binding sites.