Acute Disruption of the NMDA Receptor Subunit NR1 in the Honeybee Brain Selectively Impairs Memory Formation
Acute Disruption of the NMDA Receptor Subunit NR1 in the Honeybee Brain Selectively Impairs Memory Formation
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DOI：
10.1523/jneurosci.5543-09.2010
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发表时间：
2010-06-09
影响因子：
5.3
通讯作者：
Leboulle, Gerard
中科院分区：
文献类型：
--
作者：
Muessig, Laurenz;Richlitzki, Antje;Leboulle, Gerard
记忆形成是一个由多个阶段组成的连续过程，这些阶段可以相互独立地发展。这些阶段取决于不同大脑区域的受体激活后启动的信号通路。 NMDA 受体充当神经输入之间同时活动的传感器，因此，它在学习过程中的激活被认为对于各种形式的记忆至关重要。在这项研究中，我们利用 RNA 干扰抑制了蜜蜂大脑中 NMDA 受体 NR1 亚基的表达。我们发现，在食欲学习期间和之后不久，蜜蜂大脑蘑菇体区域亚基表达的破坏选择性地损害了记忆。尽管中期记忆和早期长期记忆的形成受到损害，但晚期长期记忆却完好无损。这表明晚期长期记忆形成与早期记忆阶段对 NMDA 受体活性的依赖不同。
Memory formation is a continuous process composed of multiple phases that can develop independently from each other. These phases depend on signaling pathways initiated after the activation of receptors in different brain regions. The NMDA receptor acts as a sensor of coincident activity between neural inputs, and, as such, its activation during learning is thought to be crucial for various forms of memory. In this study, we inhibited the expression of the NR1 subunit of the NMDA receptor in the honeybee brain using RNA interference. We show that the disruption of the subunit expression in the mushroom body region of the honeybee brain during and shortly after appetitive learning selectively impaired memory. Although the formation of mid-term memory and early long-term memory was impaired, late long-term memory was left intact. This indicates that late long-term memory formation differs in its dependence on NMDA receptor activity from earlier memory phases.