Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization
Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization
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DOI：
10.1093/carcin/21.9.1721
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发表时间：
2000-09-01
期刊：
影响因子：
4.7
通讯作者：
Waldman, FM
中科院分区：
文献类型：
--
作者：
Muscheck, M;Abol-Enein, H;Waldman, FM
膀胱肿瘤的发生与许多病原体有关，包括血吸虫病。与非血吸虫相关的膀胱癌相比，血吸虫相关的癌症显示出不同的临床和病理特征，发生在年轻患者中，并且主要是鳞状细胞类型。本研究探讨了鳞状和移行肿瘤类型之间的差异，作为肿瘤基因型和表型之间关系的衡量标准，我们使用比较基因组杂交技术分析了54例原发性肌肉浸润性膀胱肿瘤相关的染色体感染。其中26例为鳞状细胞癌，其余28例为移行细胞癌。平均而言，移行细胞肿瘤的染色体畸变数量是鳞状细胞肿瘤的1.8倍（14.4比8.2，P < 0.001）。对于两组合并，最普遍的遗传改变是8p和18q的丢失，以及8q的增加，移行细胞癌也显示出涉及5q，9p，10q，11p和11q的频繁丢失，以及1q和17q的增加。11 p缺失在TCC中的发生率显著高于SCC（50%对4%，P = 0.01）。鳞状细胞癌比移行性肿瘤显示出更频繁的17 p和18 p丢失，考虑到鳞状细胞癌变化的总体频率降低，这是明显显著的（分别为P = 0.001和P = 0.03）。这些数据表明，膀胱肿瘤的不同组织学亚组的特征在于不同的染色体改变模式。在移行细胞组中发现的遗传变化与非染色体相关的移行细胞肿瘤中报道的相似，但与呈现鳞状分化的肿瘤不同。
The development of bladder tumors has been associated with a number of causative agents, including schistosomiasis. Schistosome-related cancers show different clinical and pathological features compared with non-schistosome-related bladder cancers, occurring in younger patients, and being predominantly of squamous cell type. This study addresses the difference between squamous and transitional tumor types in the presence of schistosome infection as a measure of the relationship between tumor genotype and phenotype, We have used comparative genomic hybridization to analyze primary muscle-invasive schistosome-related bladder tumors in 54 patients. Twenty-six of these tumors were squamous cell carcinomas; the remaining 28 were of transitional cell type. On average, transitional cell tumors showed 1.8 times the number of chromosomal aberrations as squamous cell tumors (14.4 versus 8.2, P < 0.001). For both groups combined, the most prevalent genetic alterations were losses of 8p and 18q, and gains of 8q, Transitional cell cancers also showed frequent losses involving 5q, 9p, 10q, 11p and 11q, and gains at 1q and 17q. Loss of 11p was significantly more frequent in TCC than in SCC tumors (50 versus 4%, P = 0.01). Squamous cell cancers showed more frequent losses of 17p and 18p than transitional tumors, which was clearly significant given the overall reduced frequency of changes in squamous cancers (P = 0.001 and P = 0.03, respectively). These data show that different histologic subgroups of bladder tumors are characterized by distinct patterns of chromosomal alterations. The genetic changes found in the transitional cell group are similar to those reported in non-schistosome-related transitional cell tumors, but differ from tumors exhibiting squamous differentiation.