Involvement of chemokines in pain
Involvement of chemokines in pain
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DOI：
10.1016/s0014-2999(01)01311-5
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发表时间：
2001-10-19
影响因子：
5
通讯作者：
Boddeke, EWGM
中科院分区：
文献类型：
--
作者：
Boddeke, EWGM
众所周知，神经炎症在神经退行性疾病如阿尔茨海默病、中风、创伤性脑和脊髓损伤以及脱髓鞘疾病中起重要作用。同样，已经表明神经炎症在伤害感受和痛觉过敏中起重要作用。大多数关于疼痛的炎症方面的研究都涉及促炎细胞因子、胰高血糖素和生长因子的作用。最近，有研究表明趋化因子在炎症性疼痛中发挥作用。趋化因子不仅将血液中的白细胞吸引到损伤部位，而且还直接参与伤害感受。(C)出版社：Elsevier Science B.V.
It is well established that neuroinflammation plays an important role in neurodegenerative diseases like Alzheimer's disease, stroke, traumatic brain- and spinal cord injury and demyelinating diseases. Likewise, it has been suggested that neuroinflammation plays an important role in nociception and hyperalgesia. Most research concerning inflammatory aspects of pain has concerned the effects of proinflammatory cytokines, prostaglandins and growth factors. Recently, it has been suggested that chemokines play a role in inflammatory pain. Chemokines do not only attract blood leukocytes to the site of injury but also contribute directly to nociception. (C) 2001 Published by Elsevier Science B.V.