Predictors of difficulty when discontinuing postmenopausal hormone therapy
Predictors of difficulty when discontinuing postmenopausal hormone therapy
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DOI：
10.1016/j.obstetgynecol.2003.09.025
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发表时间：
2003-12-01
影响因子：
7.2
通讯作者：
Macer, JL
中科院分区：
文献类型：
--
作者：
Grady, D;Ettinger, B;Macer, JL
目的：描述绝经后妇女试图停止激素治疗的经历，并确定与无法停止激素治疗相关的特征。我们对377名随机选择的凯撒基金会健康计划女性成员进行了电话采访，年龄在50-69岁之间，在7月1日之前定期使用激素治疗至少1年，结果：377例患者中，280例（74%）成功停药，97例（26%）恢复使用激素治疗。恢复使用激素治疗的主要预测因素是出现麻烦的戒断症状（比值比8.8; 95%可信区间4.9，16.0）。子宫切除术、非妇科医生处方的激素治疗以及对髋部或脊柱骨折高风险的认知与停药失败的可能性较高独立相关。子宫切除术后使用激素治疗10年或10年以上的妇女，开始激素治疗主要是为了促进健康以外的原因，
OBJECTIVE: To describe the experiences of postmenopausal women who try to stop hormone therapy and to identify characteristics associated with inability to stop.METHODS: We conducted telephone interviews with 377 randomly selected female members of the Kaiser Foundation Health Plan, aged 50-69 years, who regularly used hormone therapy for at least 1 year before July 1, 2002 and had attempted to stop between July 2002 and March 2003.RESULTS: Of the 377 women, 280 (74%) successfully stopped and 97 (26%) resumed taking hormone therapy The major predictor of resuming hormone therapy use was the development of troublesome withdrawal symptoms (odds ratio 8.8; 95% confidence interval 4.9,16.0). Report of hysterectomy, hormone therapy prescribed by a nongynecologist, and perception of high risk of hip or spine fracture were independently associated with a higher likelihood of unsuccessful stopping. Women with a hysterectomy who had used hormone therapy for 10 or more years and who started hormone therapy mainly for reasons other than health promotion were more likely (P