Prothymosin α Restores the Depressed Autologous and Allogeneic Mixed Lymphocyte Responses in Patients with Systemic Lupus Erythematosus
Prothymosin α Restores the Depressed Autologous and Allogeneic Mixed Lymphocyte Responses in Patients with Systemic Lupus Erythematosus
复制标题
胸腺素α恢复系统性红斑狼疮患者受抑制的自体和同种异体混合淋巴细胞反应
DOI：
10.3109/08923978709035224
复制
发表时间：
1987
影响因子：
3.3
通讯作者：
G. Tsokos
中科院分区：
文献类型：
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作者：
C. Baxevanis;G. Reclos;M. Papamichail;G. Tsokos
摘要系统性红斑狼疮(SLE)以多种T细胞异常为特征，其中包括自体和异体混合淋巴细胞反应降低(自体MLR和异体MLR)。在10例SLE患者中，用氚-胸腺嘧啶核苷掺入法检测，平均自动-MLR和allo-MLR反应显著降低。在自身异基因α治疗过程中，如果给予最佳剂量的高纯度胸腺球蛋白原a(Prot MLR)，患者的T细胞增殖反应可提高至正常水平。Protα对患者较正常人有更明显的增强作用。在患者中，Protα对疾病活动性和低增殖反应的患者更有效。这些结果表明，Protα可以完全恢复系统性红斑狼疮患者自体和异体淋巴细胞反应中缺陷的T细胞增殖反应。Protα，或它的某个肽片段，可能被证明在治疗系统性红斑狼疮方面有潜在的有用。
AbstractSUMMARY Systemic lupus erythematosus (SLE) is characterized by a variety of profound T-cell abnormalities among which are decreased autologous and allogeneic mixed lymphocyte reactions (auto-MLR and allo-MLR, respectively). In a group of 10 patients with SLE, the mean auto-MLR and allo-MLR responses, tested by tritiated thymidine incorporation, were significantly decreased. If optimal doses of highly purified prothymosin a (ProT α) were present during the auto- of allo-MLR, the T-cell proliferative responses of SLE patients were increased to normal levels. ProT α had more pronouced enhancing effect in patients than in normal individuals. Among patients, ProT α was more effective in those who had active disease and low proliferative responses. These results demonstrate that ProT α can fully restore the deficient T-cell proliferative responses in auto- and allo-MLR in patients with SLE. ProT α, or a certain peptidic fragment of it, could prove potentially useful in the treatment of SLE.
在人自体混合白细胞反应中诱导免疫球蛋白分泌细胞：用单克隆抗体定义的辅助和抑制淋巴细胞亚群的调节。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gatenby,PA;Kotzin,BL;Engleman,EG
通讯作者：
Engleman,EG