Mutagenic effects of cadmium on the oocyte chromosomes of mice.
Mutagenic effects of cadmium on the oocyte chromosomes of mice.
复制标题
镉对小鼠卵母细胞染色体的致突变作用。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
A. Endo
中科院分区：
文献类型：
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作者：
Toshiaki Watanabe;T. Shimada;A. Endo
近年来，人们对环境物质的特定毒性，如诱变性、致畸性和致癌性等，引起了相当大的关注。鉴于它们对我们后代的影响，前两种性质将是非常重要的。因此，建立致突变性和致畸性的筛选方法及其合理评价已成为当务之急。人类慢性镉中毒是众所周知的gItai-itai病的临床实体，其特定毒性已在各种动物实验中进行了研究1)。至于致突变性，配子的检查将更具体地考虑其对后代的影响。因此，我们研究了体内镉对小鼠卵发生的细胞遗传学影响。这篇论文为我们的初步报告提供了额外的数据，并描述了对结果的详细分析。
During the recent years, a considerable attention has been paid to the specific toxicity of the environmental substances, such as mutagenicity, teratogenicity and carcinogenicity. In view of their influence upon our progeny, the former two properties will be of great importance. Hence, the establishment of screening methods of mutagenicity and teratogenicity and its reasonable evaluation become urgent. Human chronic poisoning of cadmium is well known as a clinical entity of •gItai-itai disease•h, and its specific toxicities have been examined in a variety of animal experiments1). As for mutagenicity, the examination of gametes will be more specific to its effect on the subsequent generations. We therefore examined the in vivo effects of cadmium on the oogenesis of the mouse cytogenetically. This paper provides additional data to our preliminary report2) and describes the detailed analysis of the results.