Microbes and Alzheimer' disease: H. pylofi and GUT microbiota
Microbes and Alzheimer' disease: H. pylofi and GUT microbiota
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DOI：
10.26355/eurrev_201901_16791
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发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Gasbarrini, A.
中科院分区：
文献类型：
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作者：
Franceschi, F.;Ojetti, V;Gasbarrini, A.
目的：微生物和慢性炎症在阿尔茨海默病（AD）发病机制中的作用已被许多作者提出。另一方面，一些研究报道了H. pylori感染和/或GUT微生物群改变在促进慢性炎症中的作用，因此可能影响AD的发生和演变。在这篇文章中，我们分析了最重要的和最新的研究在这一领域进行的人类和动物，并提供可能的致病性explanations.Results：所有主要的和最新的动物，人类，流行病学和计算机模拟研究，表明H。幽门螺杆菌和/或AD中的生态失调，主要是通过促进全身性慢性炎症和/或通过触发分子模拟机制。特别是H. pylori感染似乎与较差的认知表现有关。结论：确实，细菌已被证明通过促进炎症，诱导分子模拟机制和A β在大脑中的积累来影响神经变性。这些发现为H.幽门螺杆菌根除试验和/或GUT微生物群再调节策略。因此，现在需要进一步的研究来测试抗生素、益生菌和/或益生菌是否可以在预防AD中发挥有益作用。
OBJECTIVE: the role of microbes and chronic inflammation in the pathogenesis of Alzheimer' disease (AD) has been postulated by many authors. On the other hand, several studies have reported the main role of H. pylori infection and/or GUT microbiota alteration in promoting chronic inflammation, thus possibly influencing both occurrence and evolution of AD. In this article, we analyze the most important and recent studies performed on this field both on humans and animals and provide possible pathogenic explanations.RESULTS: all main and most recent animal, human, epidemiological and in-silico studies, showed a role of H. pylori and/or dysbiosis in AD, mostly through the promotion of systemic chronic inflammation and/or by triggering molecular mimicry mechanisms. In particular, H. pylori infection seems to be related to a poorer cognitive performance.CONCLUSIONS: Indeed, bacteria have been shown to affect neurodegeneration by promoting inflammation, inducing molecular mimicry mechanisms and accumulation of A beta into the brain. These findings open the way for H. pylori eradicating trials and/or GUT microbiota remodulating strategies. Therefore, further studies are now needed in order to test whether antibiotics, pre and/or probiotics may exert a beneficial effect in the prevention of AD.