Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome
Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome
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DOI：
10.1016/j.bbi.2006.10.009
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发表时间：
2007-07-01
影响因子：
15.1
通讯作者：
Schwartzman, Robert J.
中科院分区：
文献类型：
--
作者：
Alexander, Guillermo M.;Perreault, Marielle J.;Schwartzman, Robert J.
复杂性区域疼痛综合征是一种以感觉、自主神经、运动和营养不良的体征和症状为特征的严重慢性疼痛症状。CRPS的疼痛是持续的，随着时间的推移而恶化，而且通常与煽动事件的严重程度和持续时间不成比例。这项研究将CRPS患者脑脊液中促炎症和抗炎细胞因子、趋化因子和几种生化因子(胶质纤维酸性蛋白(GFAP)、一氧化氮代谢产物(硝酸盐和亚硝酸盐)、兴奋性氨基酸神经递质谷氨酸、钙、总蛋白和葡萄糖)水平与其他非疼痛或疼痛患者的水平进行了比较。本研究的目的是确定胶质细胞和免疫系统介质在CRPS病理生理学中的参与程度。CRPS患者的脑脊液标记物没有升高或降低。然而，有几种标志物模式可以帮助阐明疾病过程中涉及的机制和支持CRPS的诊断。最常见的是50%(11/22)的CRPS患者，包括：IL-6升高，IL-4或IL-10水平降低，GFAP或MCP1升高，以及至少两项NO代谢物、钙或谷氨酸的升高。这一类似研究的结果可能有助于阐明CRPS的病理生理学机制。对这些机制的更好理解可能会为这种非常严重、改变生活的疾病带来新的治疗方法。(C)2006 Elsevier Inc.保留所有权利。
Complex Regional Pain Syndrome is a severe chronic pain condition characterized by sensory, autonomic, motor and dystrophic signs and symptoms. The pain in CRPS is continuous, it worsens over time, and it is usually disproportionate to the severity and duration of the inciting event. This sturdy compares cerebrospinal fluid (CSF) levels of pro- and anti-inflammatory cytokines, chemokines and several biochemical factors (glial fibrillary acidic protein (GFAP), the nitric oxide metabolites (nitrate plus nitrite), the excitatory amino acid neurotransmitter glutamate, calcium, total protein and glucose) in patients afflicted with CRPS to levels found in patients suffering with other non-painful or painful conditions. The aim of the study is to determine the degree of involvement of glial cells and immune system mediators in the pathophysiology of CRPS. There was no elevation or reduction of a CSF marker that was specific for CRPS patients. However, there were several patterns of markers that could be helpful in both elucidating the mechanisms involved in the disease process and supporting the diagnosis of CRPS. The most common pattern was found in 50% (11 out of 22) of the CRPS patients and consisted of; elevated IL-6, low levels of IL-4 or IL-10, increased GFAP or MCP1 and increases in at least two of the following markers NO metabolites, calcium or glutamate. The results from this other similar studies may aid in elucidating the mechanisms involved in the pathophysiology of CRPS. A better understanding of these mechanisms may lead to novel treatments for this very severe, life-altering illness. (c) 2006 Elsevier Inc. All rights reserved.