M-CSF, c-Fms, and signaling in osteoclasts and their precursors
M-CSF, c-Fms, and signaling in osteoclasts and their precursors
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DOI：
10.1196/annals.1346.014
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Ross, F. Patrick
中科院分区：
文献类型：
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作者：
Ross, F. Patrick
预防骨质疏松症等疾病需要了解骨吸收的分子机制。髓系细胞是破骨细胞的前体，这一认识表明巨噬细胞集落刺激因子（M-CSF）在破骨细胞生物学中起着重要作用。由M-CSF与细胞表面受体c-Fms结合产生的信号似乎触发导致破骨细胞分化的事件。我们已经创建了c-Fms受体的嵌合变体，其允许在比依赖于骨髓组织的先前研究更与正常生理学相关的模型中研究由M-CSF激活的下游事件。我们的研究表明通过c-Fms受体启动的新型调节信号通路。
Prevention of conditions, such as osteoporosis, requires an understanding of the molecular mechanisms of bone resorption. The understanding that cells of the myeloid lineage are osteoclast precursors suggests that macrophage colony-stimulating factor (M-CSF) plays an important role in osteoclast biology. Signals generated by the binding of M-CSF to the cell-surface receptor c-Fms appear to trigger events leading to osteoclast differentiation. We have created a chimeric variant of the c-Fms receptor, which has allowed study of downstream events activated by M-CSF in a model more relevant to normal physiology than prior studies, which have relied on myeloid tissues. Our studies suggest novel regulatory signaling pathways initiated via the c-Fms receptor.