Nrf2 protects against TWEAK-mediated skeletal muscle wasting.
Nrf2 protects against TWEAK-mediated skeletal muscle wasting.
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Nrf2 可防止 TWEAK 介导的骨骼肌萎缩。
DOI：
10.1038/srep03625
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发表时间：
2014-01-10
影响因子：
4.6
通讯作者：
Wruck CJ
中科院分区：
文献类型：
--
作者：
Al-Sawaf O;Fragoulis A;Rosen C;Kan YW;Sönmez TT;Pufe T;Wruck CJ
Skeletal muscle (SM) regeneration after injury is impaired by excessive inflammation. Particularly, the inflammatory cytokine tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a potent inducer of skeletal muscle wasting and fibrosis. In this study we investigated the role of Nrf2, a major regulator of oxidative stress defence, in SM ischemia/reperfusion (I/R) injury and TWEAK induced atrophy. We explored the time-dependent expression of TWEAK after I/R in SM of Nrf2-wildtype (WT) and knockout (KO) mice. Nrf2-KO mice expressed significant higher levels of TWEAK as compared to WT mice. Consequently, Nrf2-KO mice present an insufficient regeneration as compared to Nrf2-WT mice. Moreover, TWEAK stimulation activates Nrf2 in the mouse myoblast cell line C2C12. This Nrf2 activation inhibits TWEAK induced atrophy in C2C12 differentiated myotubes. In summary, we show that Nrf2 protects SM from TWEAK-induced cell death in vitro and that Nrf2-deficient mice therefore have poorer muscle regeneration.
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影响因子：
3.5
作者：
De Ketelaere, A;Vermeulen, L;Moelans, I
通讯作者：
Moelans, I
DOI：
10.1161/atvbaha.110.204123
发表时间：
2010-08-01
影响因子：
8.7
作者：
Ichihara, Sahoko;Yamada, Yoshiji;Ichihara, Gaku
通讯作者：
Ichihara, Gaku
DOI：
10.1073/pnas.93.24.13943
发表时间：
1996-11-26
影响因子：
11.1
作者：
Chan, KM;Lu, RH;Kan, YW
通讯作者：
Kan, YW
影响因子：
3.7
作者：
JAHN, L;SADOSHIMA, J;IZUMO, S
通讯作者：
IZUMO, S
影响因子：
6.4
作者：
Osburn, William O.;Karim, Baktiar;Kensler, Thomas W.
通讯作者：
Kensler, Thomas W.