Self-Assembly of DNA Nanostructures Using Three-Way Junctions on Small Circular DNAs
Self-Assembly of DNA Nanostructures Using Three-Way Junctions on Small Circular DNAs
复制标题
利用小圆形 DNA 上的三向连接自组装 DNA 纳米结构
DOI：
10.1002/cnma.201700163
复制
发表时间：
2017
期刊：
影响因子：
3.8
通讯作者：
Xiao Shou-Jun
中科院分区：
文献类型：
--
作者：
Wang Meng;Afshan Noshin;Kou Bo;Xiao Shou-Jun
使用DNA作为结构构建块的分子自组装已被证明是构建纳米级物体和阵列的一条有效途径。使用预环化的DNA作为DNA基序的核心链为组装一维、二维和三维(1D、2D、3D)纳米结构提供了新的组件。我们分别报道了由三臂三角形和四臂正方形瓷砖在32-核苷酸和42-核苷酸的小环状寡核苷酸上构建的蜂窝状和网格状的纳米结构。然而，灵活的三向连接，拥挤的小圆形DNA基序的空间环境，以及双螺旋连接中缺乏刚性，可能会降低生长大型单晶DNA晶格的可能性。
Molecular self‐assembly using DNA as a structural building block has proven to be an efficient route to the construction of nanoscale objects and arrays. Using the pre‐circularised DNA as the core strand of DNA motifs provides new components for the assembly of one‐, two‐, and three‐dimensional (1D, 2D, 3D) nanostructures. We report here honeycomb‐like and grid‐like framework nanostructures constructed from 3‐arm triangle and 4‐arm square tiles with pivotal three‐way junctions on small circular oligonucleotides of 32‐nt and 42‐nt, respectively. However the flexible three‐way junction, the crowded spatial environment of the small circular DNA motifs, and the lack of rigidity in the double helix connection may reduce the possibility to grow large single crystalline DNA lattices.