A new therapeutic approach to Candida infections. A preliminary report.
A new therapeutic approach to Candida infections. A preliminary report.
复制标题
念珠菌感染的新治疗方法。
作者：
G. Medoff;W. Dismukes;R. H. Meade;J. Moses
不寻常的小剂量静脉注射阿替霉素B（10至355毫克，4至18天）是有效的治疗14例严重和致残念珠菌感染的患者。其中包括9例皮肤粘膜感染，其中强有力的局部抗真菌治疗失败。另外5名患者患有全身性疾病，对静脉导管的移除或抗生素的停用没有反应。随访2 ~ 24个月，无复发。除最大剂量的接受者出现一过性氮质血症外，未出现毒性。我们有限的经验表明，小剂量无毒的白念珠菌素B治疗皮肤粘膜和全身念珠菌感染（脑膜炎和心内膜炎除外）的疗效。
Unusually small intravenous doses of amphotericin B (10 to 355 mg given over 4 to 18 days) were effective in the treatment of 14 selected patients with severe and disabling Candida infections. These included nine with mucocutaneous infections in whom vigorous topical antifungal therapy had failed. Five other patients had systemic disease that had not responded to the removal of intravenous catheters or discontinuation of antibiotics. Follow-up over 2 to 24 months showed no recurrences. No toxicity was encountered except in the recipient of the largest dose, who had transient azotemia. Our limited experience suggests the efficacy of amphotericin B in small nontoxic doses in the treatment of mucocutaneous and systemic Candida infections, excluding meningitis and endocarditis.