Neural correlates of intolerance of uncertainty
Neural correlates of intolerance of uncertainty
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DOI：
10.1016/j.neulet.2010.05.078
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发表时间：
2010-08-02
影响因子：
2.5
通讯作者：
Schaefer, Axel
中科院分区：
文献类型：
--
作者：
Schienle, Anne;Koechel, Angelika;Schaefer, Axel
Many future events are unpredictable, which is considered unacceptable by individuals with an intolerance of uncertainty (IU). We investigated the influence of two related personality traits. IU and habitual worrying on neural correlates of affective uncertainty with functional magnetic resonance imaging. Thirty females viewed a warning cue that always preceded an aversive picture, a safety cue that always preceded a neutral picture and an uncertainty cue that signaled that an aversive or a neutral picture might be shown (probability: 50%:50%). The processing of uncertainty was associated with activation of the posterior frontomedian cortex (PFMC), the dorsolateral prefrontal cortex, and the anterior cingulate cortex. IU and habitual worrying were positively correlated with amygdala activity during experienced uncertainty. Moreover, IU correlated negatively with PFMC activity. This response pattern might reflect that uncertainty is threatening to individuals high in IU and that they lack adequate cognitive mechanism to cope with the uncertainty. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
