Platinum(II) Metallatriangle: Construction, Coassembly with Polypeptide, and Application in Combined Cancer Photodynamic and Chemotherapy
Platinum(II) Metallatriangle: Construction, Coassembly with Polypeptide, and Application in Combined Cancer Photodynamic and Chemotherapy
复制标题
铂(II)金属三角形：构建、与多肽的共组装以及在癌症光动力和化疗联合治疗中的应用
DOI：
10.1021/acs.inorgchem.1c00962
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发表时间：
2021-05-11
影响因子：
4.6
通讯作者：
Yao, Yong
中科院分区：
文献类型：
--
作者：
Zhang, Yue;Yan, Xin;Yao, Yong
不同形状、不同维数的超分子配合物的发展为其在不同领域的应用奠定了基础。在本研究中，通过“配位驱动自组装”的方法制备了卟啉基三维有机pt （II）金属三角（MTA）。采用P-31 NMR， H-1 NMR， HR-MS和理论计算对所得MTA进行了全面表征。此外，MTA与两亲性多肽（PEG-PPT）共组装制备的纳米复合材料可以在近红外辐射下生成单线态氧（O-1(2)），并在低ph微环境下释放出铂类药物。O-1(2)和Pt药物都能损伤癌细胞，从而提高癌症治疗的效率。pt -卟啉金属三角的制备扩展了其拓扑结构，可用于肿瘤联合治疗。此外，各种刺激反应基团可以修饰成三角形，因此创造了一种开发高性能生物超分子材料的新方法。
The development of the supramolecular coordination complex with different shapes and dimensionalities lays the basis for its application in different areas. In this study, a porphyrin-based 3D organo-Pt(II) metallatriangle (MTA) was fabricated through the reported method termed as "coordination driven self-assembly". P-31 NMR, H-1 NMR, HR-MS, and theoretical calculation were employed to characterize the resultant MTA fully. Furthermore, the fabricated nanocomposite through coassembly of MTA and an amphiphilic polypeptide (PEG-PPT) could generate singlet oxygen (O-1(2)) under the NIR irradiation and release a Pt drug under a low-pH microenvironment. O-1(2) and the Pt drug can both damage the cancer cells, which improves the efficiency of cancer therapies. The fabrication of a Pt-porphyrin metallatriangle expands the topological structures, and the Pt-porphyrin metallatriangle can be applied to the combined cancer therapies. Moreover, various stimuli-responsive groups can be modified to the triangle, so a new method is created to develop high-performance biosupramolecular materials.