Versatile Biocompatible Polymer Hydrogels: Scaffolds for Cell Growth
Versatile Biocompatible Polymer Hydrogels: Scaffolds for Cell Growth
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DOI：
10.1002/anie.200804096
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Bradley, Mark
中科院分区：
文献类型：
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作者：
Khan, Ferdous;Tare, Rahul S.;Bradley, Mark
将壳聚糖和聚亚胺这两种阳离子聚合物结合，制成了一种三维生物相容性水凝胶（见图）。水凝胶在细胞培养条件下稳定，促进细胞增殖，但阻止原代人骨骼细胞向成纤维细胞的去分化。各种各样的材料，如DNA、蛋白质和肽可以稳定地结合到凝胶网络中。
A three-dimensional, biocompatible hydrogel (see picture) was generated by combining two cationic polymers, chitosan and poly (ethylenimine). The hydrogels were stable under cell-culture conditions and facilitated cell proliferation, yet prevented dedifferentiation of primary human skeletal cells into fibroblasts. A variety of materials such as DNA, proteins, and peptides can be stably incorporated into the gel network.