Plasma Desmosine and Abdominal Aortic Aneurysm Disease
Plasma Desmosine and Abdominal Aortic Aneurysm Disease
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DOI：
10.1161/jaha.119.013743
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发表时间：
2019-10-15
影响因子：
5.4
通讯作者：
Choy, Anna-Maria
中科院分区：
文献类型：
--
作者：
Mordi, Ify R.;Forsythe, Rachael O.;Choy, Anna-Maria
背景--人们认识到，在预测腹主动脉瘤（AAA）疾病的预后时，主动脉大小以外的因素也很重要。AAA的特征是主动脉图尼卡中膜内的弹性蛋白分解，导致主动脉扩张和破裂。本研究的目的是调查血浆锁链素（pDES），一种弹性蛋白特异性降解产物，与AAA患者疾病严重程度和临床结果的关系。方法和结果-我们测量了507例AAA患者的pDES和血清生物标志物浓度（94%男性;平均年龄，72.4 ± 6.1岁;平均AAA直径，48 ± 8 mm）和来自2项观察性队列研究的162例对照受试者（100%男性;平均年龄，71.5 ± 4.4岁）。在纵向队列研究（n=239）中，我们探讨了pDES对AAA事件的增量预后价值。腹主动脉瘤患者的pDES高于对照组（平均值+/- SD：0.46 +/- 0.22 vs 0.33 +/- 0.16 ng/mL; P
Background-It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and rupture. The aim of this study was to investigate the association of plasma desmosine (pDES), an elastin-specific degradation product, with disease severity and clinical outcome in patients with AAA.Methods and Results-We measured pDES and serum biomarker concentrations in 507 patients with AAAs (94% men; mean age, 72.4 +/- 6.1 years; mean AAA diameter, 48 +/- 8 mm) and 162 control subjects (100% men; mean age, 71.5 +/- 4.4 years) from 2 observational cohort studies. In the longitudinal cohort study (n=239), we explored the incremental prognostic value of pDES on AAA events. pDES was higher in patients with AAA compared with control subjects (mean +/- SD: 0.46 +/- 0.22 versus 0.33 +/- 0.16 ng/mL; P