Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa
Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa
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DOI：
10.1021/np049949f
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发表时间：
2004-08-01
影响因子：
5.1
通讯作者：
Scheuer, PJ
中科院分区：
文献类型：
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作者：
Nakao, Y;Yoshida, WY;Scheuer, PJ
细胞毒性缩酚肽 kulokekahilide-2 (1) 是从头足类软体动物 Philinopsis spiosa 中分离出来的。通过光谱分析和化学降解对kulokekahilide-2进行了结构解析。 Kulokekahilide-2 对多种细胞系（P388、SKOV-3、MDA-MB-435 和 A-10，IC50 值范围为 4.2 至 59.1 nM）显示出有效的细胞毒性，表明癌细胞具有选择性。
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SKOV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.