Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain
Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain
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DOI：
10.1002/jmri.22987
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发表时间：
2007-08-01
影响因子：
4.4
通讯作者：
Kirsch, Wolff
中科院分区：
文献类型：
--
作者：
Haacke, E. Mark;Ayaz, Muhammad;Kirsch, Wolff
目的：建立人脑多个区域组织间相位差的基线，作为利用磁共振成像(MRI)检测铁异常的手段。材料和方法：采用完全流动补偿的三维(31个)高分辨率梯度回波(GRE)磁化率加权成像(SWI)序列，采集1.5T的幅度和相位数据。相位图像经过高通滤波，逐区处理，手工绘制区域。被评估的区域包括运动皮质(MC)、壳核(Put)、苍白球(GP)、尾状核(CN)、黑质。(SN)和红核(RN)。对75名年龄从55岁到89岁的受试者进行了分析。结果：相位呈类高斯型分布，标准偏差(SD)为0.046弧度。大多数感兴趣区域(ROI)至少包含100个像素，平均(扫描电子显微镜)的标准误差为0.0046弧度或更小。在MC中，脑脊液与灰质(GM)之间的相位差约为0.273弧度，脑脊液与白质(WM)之间的相位差约为0.083弧度。脑脊液与GP的差值为0.201弧度，脑脊液与CN(头部)的差值为0.213弧度。脑脊液和PUT(外侧下方)的差值为0.449弧度，脑脊液与第三层血运区域(RN)的差值为0.353弧度。最后，脑脊液和SN的相位差为0.345弧度。结论：脑组织的相位分布呈类高斯分布，可以预测脑组织偏离正常相位行为的情况。在帕金森氏症、亨廷顿氏症、神经变性伴脑铁蓄积(NBIA)、阿尔茨海默氏症和多发性硬化症(MS)以及其他铁相关疾病中，使用相作为铁的标志物可能有助于研究-铁的吸收。这里引用的阶段将作为未来寻找铁含量变化的研究的基线。
Purpose: To establish a baseline of phase differences between tissues in a number of regions of the human brain as a means of detecting iron abnormalities using magnetic resonance imaging (MRI).Materials and Methods: A fully flow-compensated, three-dimensional (31)), high-resolution, gradient-echo (GRE) susceptibility-weighted imaging (SWI), sequence was used to collect magnitude and phase data at 1.5T. The phase images were high-pass-filtered and processed region by region with hand-drawn areas. The regions evaluated included the motor cortex (MC), putamen (PUT), globus pallidus (GP), caudate nucleus (CN), substantia nigra. (SN), and red nucleus (RN). A total of 75 subjects, ranging in age from 55 to 89 years, were analyzed.Results: The phase was, found to have a Gaussian-like distribution with a standard deviation (SD) of 0.046 radians on a pixel-by-pixel basis. Most regions of interest (ROIs) contained at least 100 pixels, giving a standard error of the mean (SEM) of 0.0046 radians or less. In the MC, phase differences were found to be roughly 0.273 radians between CSF and gray matter (GM), and 0.083 radians between CSF and white matter (WM). The difference between CSF and the GP was 0.201 radians, and between CSF and the CN (head) it was 0.213 radians. For CSF and the PUT (the lower outer part) the difference was 0.449 radians, and between CSF and the RN (third slice vascularized region) it was 0.353 radians. Finally, the phase difference between CSF and SN was 0.345 radians.Conclusion: The Gaussian-like distributions in phase make it possible to predict deviations from normal phase behavior for tissues in the brain. Using phase as an iron marker may be useful for studying absorption of-iron in diseases such as Parkinson's, Huntington's, neurodegeneration with brain iron accumulation (NBIA), Alzheimer's, and multiple sclerosis (MS), and other iron-related diseases. The phases quoted here will serve as a baseline for future studies that look for changes in iron content.