Acquisition of cytomegaloviral infections in families with young children: a serological study.
Acquisition of cytomegaloviral infections in families with young children: a serological study.
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有幼儿的家庭中巨细胞病毒感染的获得：血清学研究。
DOI：
10.1093/infdis/151.5.948
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Bagley,A
中科院分区：
文献类型：
--
作者：
Taber,LH;Frank,AL;Yow,MD;Bagley,A
通过使用 ELISA 和抗补体免疫荧光法对巨细胞病毒 (CMV) 抗体进行系列血清学检测，研究了有幼儿的家庭中巨细胞病毒 (CMV) 感染的情况。休斯顿 68 个家庭的成员接受了平均 3.5 年的研究。在所研究的 68 个家庭中，有 37 个家庭 (53%) 的一名或多名成员发生了血清转化。父亲的平均年血清转化率为 10%，母亲为 10.6%，儿童为 10.3%。易感家庭成员（包括指示病例）的发病率为54%。指示病例有 10 例为儿童，2 例为父亲，2 例为母亲。23 个家庭无法确定指示病例。休斯顿的这项研究表明，有幼儿的家庭是巨细胞病毒感染的高危环境。这是关于母亲在生育和抚养孩子期间面临的风险的一个重要问题。
Acquisition of cytomegalovirus (CMV) infection in families with young children was investigated with serial serological tests for antibody to CMV by using ELISA and anticomplement immunoflourescence. Members of 68 Houston families were studied for a mean of 3.5 years. Seroconversion occurred in one or more members of 37 (53%) of 68 families studied. The mean annual seroconversion rate was 10% for fathers, 10.6% for mothers, and 10.3% for children. The attack rate for susceptible family members (including the index case) was 54%. The index case was the child in 10 instances, the father in 2, and the mother in 2. The index case could not be identified in 23 families. This Houston study indicates that the family with young children is a high-risk setting for CMV infection. This is an important concern regarding risks for mothers in their childbearing and child-rearing years.