THE STRUCTURE OF PROTEINS - 2 HYDROGEN-BONDED HELICAL CONFIGURATIONS OF THE POLYPEPTIDE CHAIN
THE STRUCTURE OF PROTEINS - 2 HYDROGEN-BONDED HELICAL CONFIGURATIONS OF THE POLYPEPTIDE CHAIN
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DOI：
10.1073/pnas.37.4.205
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发表时间：
1951-01-01
影响因子：
11.1
通讯作者：
BRANSON, HR
中科院分区：
文献类型：
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作者：
PAULING, L;COREY, RB;BRANSON, HR
在过去的15年里，我们一直在用几种方法研究蛋白质的结构问题。这些方法之一是完整而准确地测定氨基酸、肽和其他与蛋白质有关的简单物质的晶体结构，以便获得关于原子间距离、键角和其他构型参数的信息，从而可以可靠地预测多肽链的合理构型。我们现在已经利用这一信息为多肽链构建了两种合理的氢键螺旋构型;我们认为，这些构型很可能构成纤维蛋白和球状蛋白以及合成多肽结构的重要组成部分。去年发表了一封宣布他们发现的信。“我们给自己提出的问题是找到一条多肽链的所有氢键结构，其中残基是
During the past fifteen years we have been attacking the problem of the structure ofproteins in several ways. One of these ways is the complete and accurate determination of the crystal structure of amino acids, pep-tides, and other simple substances related to proteins, in order that infor-mation about interatomic distances, bond angles, and other configurational parameters might be obtained that would permit the reliable prediction of reasonable configurations for the polypeptide chain. We have now used this information to construct two reasonable hydrogen-bonded helical con-figurations for the polypeptide chain; wte think that it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of synthetic polypeptides. A letter an-nouncing their discovery was published last year.'The problem that we have set ourselves is that of finding all hydrogen-bonded structures for a single polypeptide chain, in which the residues are