Preexposure to PM2.5 exacerbates acute viral myocarditis associated with Th17 cell.
Preexposure to PM2.5 exacerbates acute viral myocarditis associated with Th17 cell.
复制标题
预先暴露于 PM2.5 会加剧与 Th17 细胞相关的急性病毒性心肌炎。
DOI：
10.1016/j.ijcard.2013.06.025
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发表时间：
2013-10
影响因子：
3.5
通讯作者：
Zhao, Jinzhuo
中科院分区：
文献类型：
--
作者：
Xie, Yuquan;Zhang, Xian;Tian, Zhenyong;Jiang, Rongfang;Chen, Ruizhen;Song, Weimin;Zhao, Jinzhuo
BackgroundIt is increasingly recognized that exposure to ambient fine particles (PM2.5) is a risk factor for the development of cardiovascular events. This study was to explore the link between PM2.5exposure and viral myocarditis in the functional mechanism of Th17 cells.MethodsMale BALB/c mice were administered an intratracheal (i.t.) instillation of 10 mg/kg b.w. PM2.5particles. Twenty-four hours later, the mice were injected intraperitoneally (i.p.) with 100 μl of coxsackievirus B3 (CVB3) diluted in Eagle's minimal essential medium (EMEM). Seven days after the treatment, pulmonary and cardiac tissues were examined.ResultsThe results showed that preexposure to PM2.5increased the cardiac and pulmonary injuries and viral replication in the heart of CVB3-infected mice along with an increase in CD4+IL-17+cells in the spleen and heart. The mRNA expressions of interleukin-17A (IL-17A), perforin, transforming growth factor-β (TGF-β) and RORγt were up-regulated in PM2.5-pretreated mice than that in the virus-treated mice. Additionally, compared to virus-treated mice, the cardiac protein expressions of IL-17A and matrix metalloproteinases-2 (MMP-2) were increased, but interferon-γ (IFN-γ) and metalloproteinases-1 (TIMP-1) were decreased in PM2.5-pretreated mice. Interestingly, PM2.5caused IFN-γ decreased, whereas CVB3 caused a dramatic increase in IFN-γ. Subsequently, preexposure to PM2.5induced a slight increase of IFN-γ in the sera of CVB3-infected mice.ConclusionsThese results demonstrated that PM2.5exposure exacerbated virus-induced myocarditis possibly through the increase in Th17-mediated viral replication, perforin response and imbalance of MMP-2/TIMP-1. These findings provided supportive evidence for the epidemiological research that ambient particles could increase the occurrence and development of cardiovascular diseases.
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影响因子：
37.8
作者：
Pope, CA;Burnett, RT;Godleski, JJ
通讯作者：
Godleski, JJ
DOI：
10.1152/ajpheart.00928.2007
发表时间：
2007-12-01
影响因子：
4.8
作者：
Cortez, Dolores M.;Feldman, Marc D.;Chandrasekar, Bysani
通讯作者：
Chandrasekar, Bysani
DOI：
10.1007/s00281-006-0043-2
发表时间：
2006-08
期刊：
Springer Seminars in Immunopathology
影响因子：
--
作者：
S. Sakaguchi
通讯作者：
S. Sakaguchi
影响因子：
2.1
作者：
Chen LC;Quan C;Hwang JS;Jin X;Li Q;Zhong M;Rajagopalan S;Sun Q
通讯作者：
Sun Q
影响因子：
3.5
作者：
Jinzhuo Zhao;Yuquan Xie;Xiaolin Qian;R. Jiang;Weimin Song
通讯作者：
Jinzhuo Zhao;Yuquan Xie;Xiaolin Qian;R. Jiang;Weimin Song