Electrophilic and redox properties of diesel exhaust particles
Electrophilic and redox properties of diesel exhaust particles
复制标题
DOI：
10.1016/j.envres.2008.12.008
复制
发表时间：
2009-04-01
影响因子：
8.3
通讯作者：
Cho, Arthur K.
中科院分区：
文献类型：
--
作者：
Shinyashiki, Masaru;Eiguren-Fernandez, Arantza;Cho, Arthur K.
空气污染物对健康的不利影响与其氧化还原和亲电子特性有关。虽然参与这些影响的具体化学物质尚不清楚，但对其一般物理和化学特性的表征对于我们了解其引起健康问题的机制至关重要。这份手稿描述了一项研究的结果，研究这些活动在水和有机介质中的分配特性。采用本实验室早期开发的测定方法，测定了七种柴油机排气颗粒（DEP）样品的氧化还原活性和亲电组分在水和二氯甲烷（DCM）中的溶解度。表现出氧化还原活性的组分，其中包括金属和非金属物种，与水悬浮液中的颗粒。部分氧化还原活性化合物也是DCM可溶的。相反，亲电成分包括水溶性和DCM可溶性物质。醌类或醌类化合物在DCM可溶性成分的氧化还原和亲电活性中的作用通过还原乙酰化来评估，还原乙酰化是使醌类失活的程序。实验结果表明，有机提取物中的大部分活性与醌类物质有关。由于颗粒物和溶质的毒性相当不同，因此活性物质的分配特性在暴露评估中很重要。(C)2008年爱思唯尔公司All rights reserved.
The adverse health effects of air pollutants have been associated with their redox and electrophilic properties. Although the specific chemical species involved in these effects are not known, the characterization of their general physical and chemical properties is important to our understanding of the mechanisms by which they cause health problems. This manuscript describes results of a study examining the partition properties of these activities in aqueous and organic media. The water and dichloromethane (DCM) solubility of redox active and electrophilic constituents of seven diesel exhaust particle (DEP) samples were determined with assays developed earlier in this laboratory. The constituents exhibiting redox activity, which included both metals and nonmetal species, were associated with the particles in the aqueous suspensions. Portions of the redox active compounds were also DCM-soluble. In contrast, the electrophilic constituents included both water-soluble and DCM-soluble species. The role of quinones or quinone-like compounds in redox and electrophilic activities of the DCM-soluble constituents was assessed by reductive acetylation, a procedure that inactivates quinones. The results from this experiment indicated that most of the activities in the organic extract were associated with quinone-like substances. The partition properties of the reactive species are important in exposure assessment since the toxicokinetics of particles and solutes are quite distinct. (C) 2008 Elsevier Inc. All rights reserved.