EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR-II (IGF-II) IN HUMAN HEPATOCELLULAR CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY
EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR-II (IGF-II) IN HUMAN HEPATOCELLULAR CARCINOMAS - AN IMMUNOHISTOCHEMICAL STUDY
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DOI：
10.1111/j.1440-1827.1994.tb01697.x
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发表时间：
1994-02-01
影响因子：
2.2
通讯作者：
BRECHOT, C
中科院分区：
文献类型：
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作者：
DERRICO, A;GRIGIONI, WF;BRECHOT, C
最近的研究结果表明，胰岛素样生长因子II（IGF-II）在肝细胞癌（HCC）的发病机制中可能发挥作用。为了研究这一现象，使用抗IGF-II的单克隆抗体对54例HCC患者进行研究。还在血清和肝组织中检测了HBsAg的存在。在9/15（60%）的HCC中发现了阳性免疫反应，这些HCC发生在具有HBV血清标志物的患者（HBV+患者）的肝硬化肝脏中。这些结果提供了进一步的证据，HBV可能在IGF-II的表达中发挥作用。在没有任何HBV感染标志物的HCC患者（HBV阴性患者）中，在10/39（25.6%）的肿瘤和一些良性肿瘤性病变中检测到IGF-II。它不仅见于肿瘤细胞，也见于一些不典型增生的结节。推测IGF-II表达可能在肝癌发生的某些步骤中起作用。
Recent results obtained using molecular biology techniques have suggested a possible role for insulin-like growth factor II (IGF-II) in the pathogenesis of hepatocellular carcinoma (HCC). To investigate this phenomenon, a monoclonal antibody was used against IGF-II to study 54 patients with HCC. The presence of HBsAg was also tested both in serum and liver tissue. A positive immunoreaction was found in 9/15 (60%) of the HCC arising in cirrhotic livers of patients who had serum markers for HBV (HBV+ positive patients). These results provide further evidence that HBV might play a role in the expression of IGF-II. In HCC of patients without any markers of HBV infection (HBV- negative patients), IGF-II was detected in 10/39 (25.6%) of the tumors, and in some benign neoplastic lesions. It was found not only in neoplastic cells but also in some dysplastic nodules. The speculation arises that IGF-II expression may play a role in some steps of hepato-carcinogenesis.