QUANTITATIVE MAGNETIC-RESONANCE-IMAGING OF THE LUMBAR SPINE - POTENTIAL FOR INVESTIGATIONS OF WATER-CONTENT AND BIOCHEMICAL-COMPOSITION
QUANTITATIVE MAGNETIC-RESONANCE-IMAGING OF THE LUMBAR SPINE - POTENTIAL FOR INVESTIGATIONS OF WATER-CONTENT AND BIOCHEMICAL-COMPOSITION
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DOI：
10.1097/00007632-199511000-00018
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发表时间：
1995-11-01
期刊：
影响因子：
3
通讯作者：
BOESCH, C
中科院分区：
文献类型：
--
作者：
BOOS, N;BOESCH, C
定量磁共振成像（弛豫时间和质子密度测量）作为一种非侵入性的方法来研究腰椎间盘和椎体的含水量和生化成分的变化，已获得越来越多的关注。本文综述了目前的方法学问题和可行性的定量磁共振成像在腰椎的含水量和生物组成的调查。该技术不允许直接定量含水量。虽然生化变化可能会敏感地影响弛豫时间和质子密度在体外条件下，它是不可行的，以获得足够的可靠和具体的信息，以监测生化变化与腰椎间盘病变在体内。
Ouantitative magnetic resonance imaging (relaxation time and proton density measurements) has gained increasing interest as a noninvasive way to study changes in water content and biochemical composition of lumbar intervertebral discs and vertebral bodies. This article reviews the current methodological problems and the feasibility of quantitative magnetic resonance imaging in the lumbar spine for investigations on water content and biological composition. This technique does not allow direct quantification of water content. Although biochemical variations may sensitively influence relaxation times and proton density under in vitro conditions, it is not feasible to obtain sufficiently reliable and specific information to monitor biochemical alterations associated with lumbar disc pathology in vivo.