TOXIC ACTION OF SEVERAL LETHAL CONCENTRATIONS OF AN ANIONIC DETERGENT ON GILLS OF BROWN TROUT (SALMO-TRUTTA-L)
TOXIC ACTION OF SEVERAL LETHAL CONCENTRATIONS OF AN ANIONIC DETERGENT ON GILLS OF BROWN TROUT (SALMO-TRUTTA-L)
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DOI：
10.1111/j.1095-8649.1976.tb04692.x
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发表时间：
1976-01-01
影响因子：
2
通讯作者：
ABEL, PD
中科院分区：
文献类型：
--
作者：
ABEL, PD
研究了10种致死浓度的阴离子去污剂十二烷基硫酸钠对日本血吸虫鳃的病理影响。用光学显微镜和透射电镜对真核生物进行了研究。在浓度为120 mg/l时（中等存活时间> 1 h），上皮细胞死亡与溶酶体形成相关。鳃组织急性炎症，上皮细胞广泛脱落，除最低浓度外，柱细胞系统崩溃。在浓度高于120 mg/l时（培养基存活时间< 1 h），细胞的快速裂解导致细胞和组织结构的完全破坏。鳃的总体结构的变化可以用细胞水平上的毒性作用的速率和性质来解释。生物医学文献综述表明，十二烷基硫酸钠对鳃细胞的影响与洗涤剂导致分离细胞死亡的2种机制相对应。这些是自溶，即，通过细胞自身酶的作用（由细胞膜中的初始损伤（其确切性质未知）诱导）进行的裂解，以及通过去污剂对细胞成分的直接作用进行的快速裂解。
The pathological effects of 10 lethal concentrations of the anionic detergent, sodium lauryl sulfate, on the gills of S. trutta were studied by light microscopy and EM. At concentrations to 120 mg/l (medium survival times > 1 h), epithelial cell death is associated with lysosome formation. Acute inflammation of the gill tissue, extensive detachment of the epithelium and, except at the lowest concentrations, collapse of the pillar cell system occur. At concentrations above 120 mg/l (medium survival times < 1 h) very rapid lysis of cells results in the complete disruption of cellular and tissue structure. Changes in the gross structure of the gills are explainable in terms of the rate and nature of toxic action at the cellular level. Review of the biomedical literature suggests the observed effects of sodium lauryl sulfate on gill cells correspond to the 2 mechanisms by which detergents cause death in isolated cells. These are autolysis, i.e., lysis by the action of the cell''s own enzymes, induced by an initial lesion in the cell membrane whose precise nature is not known, and rapid lysis by the direct action of the detergent on the cell constituents.