Specificity of regional brain activity in anxiety types during emotion processing
Specificity of regional brain activity in anxiety types during emotion processing
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DOI：
10.1111/j.1469-8986.2007.00518.x
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发表时间：
2007-05-01
期刊：
影响因子：
3.7
通讯作者：
Miller, Gregory A.
中科院分区：
文献类型：
--
作者：
Engels, Anna S.;Heller, Wendy;Miller, Gregory A.
本研究验证了这一假设，即焦虑的忧虑涉及更多的左半球比右半球的活动和焦虑的觉醒与相反的模式。行为和功能磁共振成像反应的威胁刺激的情绪Stroop任务进行了检查，在非病人组报告焦虑的恐惧，焦虑的觉醒，或两者都没有。消极词的反应时间比中性词的反应时间长。正如预测的那样，大脑激活区分焦虑组在左下额叶区域与语音生产和右半球下颞区。关于左额叶参与情绪的第二个假设，不同的左额叶区域与焦虑的理解和积极信息的处理有关。结果支持提出的两种类型的焦虑之间的区别，并解决不一致的左额叶激活的情绪和精神病理学的作用。
The present study tested the hypothesis that anxious apprehension involves more left- than right-hemisphere activity and that anxious arousal is associated with the opposite pattern. Behavioral and fMRI responses to threat stimuli in an emotional Stroop task were examined in nonpatient groups reporting anxious apprehension, anxious arousal, or neither. Reaction times were longer for negative than for neutral words. As predicted, brain activation distinguished anxious groups in a left inferior frontal region associated with speech production and in a right-hemisphere inferior temporal area. Addressing a second hypothesis about left-frontal involvement in emotion, distinct left frontal regions were associated with anxious apprehension versus processing of positive information. Results support the proposed distinction between the two types of anxiety and resolve an inconsistency about the role of left-frontal activation in emotion and psychopathology.