The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy:: a multicenter, retrospective analysis
The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy:: a multicenter, retrospective analysis
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DOI：
10.1016/j.radonc.2004.12.021
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发表时间：
2005-02-01
影响因子：
5.7
通讯作者：
de Torres, I
中科院分区：
文献类型：
--
作者：
Giralt, J;de las Heras, M;de Torres, I
背景与目的：50-70%的结直肠癌中观察到表皮生长因子受体（EGFR）的表达，并且与不良预后相关。本研究的目的是确定一组接受术前放疗的局部晚期直肠癌患者放疗前 EGFR 状态的预后价值。 患者和方法：对 87 例患者进行回顾性研究。 50 名患者的治疗包括盆腔放疗，同时进行化疗和手术切除。在放射前活检和切除的标本中测定 EGFR 的免疫组织化学。根据延伸和染色强度评估 EGFR 表达的免疫组织化学分析。当延伸为 5% 或更多时，我们定义阳性染色（EGFR 阳性）。结果：87 个肿瘤中共有 52 个肿瘤在活检时显示 EGFR 阳性状态（60%），并且 EGFR 表达既与临床肿瘤分期也不与临床淋巴结分期相关。 EGFR 阳性表达与术前放疗缺乏病理完全缓解相关（P = 0.006）。放疗前 EGFR 阳性的患者的无病生存率较低（P = 0.003）。在多变量分析中，活检时 EGFR 表达是无病生存率的统计学显着预测因子，RR = 2.88 (1.1-7.8)，P = 0.036。结论：EGFR 在大量直肠肿瘤中表达。放疗前 EGFR 阳性表达是反应不佳和无病生存率低的指标。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Background and purpose: Expression of epidermal growth factor receptor (EGFR) is observed in 50-70% of colorectal carcinoma and is associated with poor prognosis. The aim of this study was to determine the prognostic value of EGFR status before radiotherapy in a group of patients with locally advanced rectal cancer treated with preoperative radiotherapy.Patients and methods: Eighty-seven patients were studied retrospectively. Treatment consisted of pelvic radiotherapy, in 50 patients with concomitant chemotherapy and surgical resection. Immunohistochemistry for EGFR was determined at the preradiation biopsy and in the resected specimens. Immunohistochemical analysis for EGFR expression was evaluated according to extension and staining intensity. We defined positive staining (EGFR positive), when extension was 5% or more.Results: A total of 52 of 87 tumors showed EGFR positive status at biopsy (60%) and EGFR expression was associated neither with clinical tumor stage nor with clinical nodal stage. EGFR positive expression was linked to a lack of pathologic complete response to preoperative radiotherapy (P = 0.006). Disease-free survival was lower among patients with EGFR positive status before radiotherapy (P = 0.003). In a multivariate analysis EGFR expression at biopsy was a statistically significant predictor of disease-free survival, RR = 2.88 (1.1-7.8), P = 0.036.Conclusions: EGFR is expressed in a significant number of rectal tumors. EGFR-positive expression before radiotherapy is an indicator for poor response and low disease-free survival. (c) 2005 Elsevier Ireland Ltd. All rights reserved.