Pathophysiological functions of self-derived DNA
Pathophysiological functions of self-derived DNA
复制标题
DOI：
10.1080/08830185.2022.2070616
复制
发表时间：
2022-05
影响因子：
5
通讯作者：
D. Ori;T. Kawai
中科院分区：
文献类型：
--
作者：
D. Ori;T. Kawai
摘要炎症在建立免疫应答如获得性免疫中起着不可或缺的作用。此外，它对于在不断变化的条件下维持生物体内平衡至关重要。模式识别受体（PRR）存在于细胞膜、内体或细胞质中，并作为炎症反应的触发器发挥作用。病原体或自身衍生的组分（如DNA）与PRR的结合激活下游信号传导级联，导致产生一系列促炎细胞因子和I型干扰素（IFN）。虽然这一系列的反应对于宿主防御是必不可少的，但DNA从宿主细胞的细胞核或线粒体中意外释放可导致自身免疫性和自身炎症性疾病。在这篇综述中，我们重点介绍了通过PRRs的DNA传感机制和自衍生DNA引起的疾病和异常情况。图形摘要
Abstract Inflammation plays indispensable roles in building the immune responses such as acquired immunity against harmful pathogens. Furthermore, it is essential for maintaining biological homeostasis in ever-changing conditions. Pattern-recognition receptors (PRRs) reside in cell membranes, endosomes or cytoplasm, and function as triggers for inflammatory responses. Binding of pathogen- or self-derived components, such as DNA, to PRRs activates downstream signaling cascades, resulting in the production of a series of pro-inflammatory cytokines and type I interferons (IFNs). While these series of responses are essential for host defense, the unexpected release of DNA from the nucleus or mitochondria of host cells can lead to autoimmune and autoinflammatory diseases. In this review, we focus on DNA-sensing mechanisms via PRRs and the disorders and extraordinary conditions caused by self-derived DNA. Graphical Abstract