PRIMARY EPSTEIN-BARR VIRUS-INFECTIONS IN AFRICAN INFANTS - DECLINE OF MATERNAL ANTIBODIES AND TIME OF INFECTION
PRIMARY EPSTEIN-BARR VIRUS-INFECTIONS IN AFRICAN INFANTS - DECLINE OF MATERNAL ANTIBODIES AND TIME OF INFECTION
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DOI：
10.1002/ijc.2910220304
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发表时间：
1978-01-01
影响因子：
6.4
通讯作者：
HENLE, G
中科院分区：
文献类型：
--
作者：
BIGGAR, RJ;HENLE, W;HENLE, G
婴儿（31）生活在阿克拉，加纳，一个地区的地方性伯基特淋巴瘤，每月一次访问的前15个月。在21个月时再次进行。通过免疫荧光技术检测每次访视时获得的血清中EB病毒（EBV）衣壳抗原（VCA）、EBV诱导早期抗原（EA）和EBV相关核抗原（EBNA）的抗体，并检测EBV中和抗体和抗体依赖性细胞介导的细胞溶解。所有婴儿在1个月时都有VCA的母体抗体。年龄和大多数也有抗体检测的其他测试，除了抗EA。根据近5周的半衰期，母体抗VCA滴度在随后的几个月内下降。根据初始滴度，所有婴儿在2-8个月时所有抗体均为血清阴性。抗VCA持续时间最长。原发性EBV感染最早出现在第3个月。母亲的抗VCA抗体检测不到后到12个月。在15个月时，44%的婴儿血清转化，62%，到21个月，百分之八十一感染率没有季节性变化。来自社会经济水平最低的家庭的婴儿往往比来自较好家庭的婴儿更早感染（P = 0.22），但没有其他因素，如家庭规模或拥挤，似乎与早期感染的风险增加有关。
Infants (31) living in Accra, Ghana, an area endemic for Burkitt''s lymphoma, were visited at monthly intervals for the first 15 mo. of life and once again at 21 mo. Sera obtained at each visit were tested for antibodies to Epstein-Barr virus (EBV) capsid antigen (VCA), EBV-induced early antigens (EA) and EBV-associated nuclear antigen (EBNA) by immunofluorescence techniques and for EBV-neutralizing antibodies and antibody-dependent cell-mediated cytolysis. All infants had maternal antibodies to VCA at 1 mo. of age and the majority also had antibodies detected by the other tests, except anti-EA. The maternal anti-VCA titers declined in subsequent months according to a half-life of nearly 5 wk. Depending on the initial titers, all infants became seronegative for all antibodies by 2-8 mo. of age, with anti-VCA persisting longest. The earliest primary EBV infection occurred in the 3rd mo. after maternal antibodies to VCA became non-detectable. By 12 mo. of age, 44% of the infants seroconverted, by 15 mo., 62% and by 21 mo., 81%. There was no seasonal variation in the incidence of infections. Infants from families of the lowest socio-economic level tended to become infected somewhat earlier than those from better situated families (P = 0.22) but no other factors, such as household size or crowding, seemed to be associated with enhanced risk of early infection.