Embryonic development of the CNS microvasculature in the mouse: new insights into the structural mechanisms of early angiogenesis.
Embryonic development of the CNS microvasculature in the mouse: new insights into the structural mechanisms of early angiogenesis.
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小鼠中枢神经系统微血管的胚胎发育：对早期血管生成结构机制的新见解。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
H. Bauer
中科院分区：
文献类型：
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作者：
H. Bauer;M. Steiner;H. Bauer
本文应用超微结构技术研究了小鼠胚胎发育过程中中枢神经系统血管化及血脑屏障（bbb）相关形态学特征的表达。在第9天（E9），仅在神经周间充质组织中发现毛细血管，表现出开窗和松散附着的周细胞。在E10，内皮细胞（EC）与周细胞和其他间充质细胞一起侵入神经内域。当新的神经内毛细血管形成时，迁移的EC表现出许多突起，并失去了它们的开窗。神经内EC细胞核突出，胞饮小泡增多，连接复合体紧密。这些结果表明，从神经内血管形成的第一天起，血脑屏障的形态特征就存在于早期胚胎小鼠大脑皮层中。
Vascularization and expression of blood-brain barrier (bbb) associated morphological characteristics were studied by ultrastructural analysis during the embryonic development of the mouse CNS. At day 9 (E9) capillaries were only found in the perineural mesenchymal tissue exhibiting fenestrations and loosely attached pericytes. At E10 endothelial cells (EC) together with pericytes and other mesenchymal cells invaded the intraneural domain. The immigrating EC showed numerous protrusions and lost their fenestrations as soon as the new intraneural capillaries were formed. Intraneural EC showed prominent nuclei, many pinocytotic vesicles and junctional complexes which appeared tight in some places. These results indicate that from the first day of intraneural vascularization onwards, the morphological properties of the bbb are present in the early embryonic mouse cerebral cortex.