GENERATION OF 3-(1H-ISOCHROMEN-1-YL)-1H-INDOLE VIA SILVER TRIFLATE-CATALYZED TANDEM REACTION OF 2-ALKYNYLBENZALDEHYDE WITH INDOLE
GENERATION OF 3-(1H-ISOCHROMEN-1-YL)-1H-INDOLE VIA SILVER TRIFLATE-CATALYZED TANDEM REACTION OF 2-ALKYNYLBENZALDEHYDE WITH INDOLE
复制标题
三氟甲磺酸银催化 2-炔基苯甲醛与吲哚的串联反应生成 3-(1H-异铬-1-YL)-1H-吲哚
DOI：
10.3987/com-10-s(e)68
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发表时间：
2011-03-01
期刊：
影响因子：
0.6
通讯作者：
Wu, Jie
中科院分区：
文献类型：
--
作者：
Ouyang, Banlai;Yuan, Jianjun;Wu, Jie
以吲哚和2-炔基苯甲醛为原料，三氟甲磺酸银为催化剂，通过串联反应合成了3-（1H-异色烯-1-基）-1H-吲哚。反应在DMF中于室温下顺利进行，具有良好的底物通用性。起始材料的可用性结合温和的反应条件和该合成路线的高效率将是有吸引力的，并且有利于集中的文库构建。
A facile and efficient method is developed for synthesis of 3-(1H-isochromen-1-yl)-1H-indole via silver triflate-catalyzed tandem reaction of 2-alkynylbenzaldehyde with indole. The reaction proceeds smoothly in DMF at room temperature with good substrate generality. The availability of the starting materials combined with mild reaction conditions and the high efficiency of this synthetic route would be attractive and beneficial for the focused library construction.